SPARQL | HTML5 RDFa and Microdata document
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http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
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http://purl.obolibrary.org/obo/DOID_2055
http://purl.obolibrary.org/obo/DOID_319
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http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/21673720
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/18267965
https://identifiers.org/pubmed/17629414
https://identifiers.org/pubmed/17698296
https://identifiers.org/pubmed/17706365
https://identifiers.org/pubmed/17917587
https://identifiers.org/pubmed/23152062
https://identifiers.org/pubmed/22884909
https://identifiers.org/pubmed/22930444
https://identifiers.org/pubmed/23035104
https://identifiers.org/pubmed/21640756
https://identifiers.org/pubmed/21657851
https://identifiers.org/pubmed/22536415
https://identifiers.org/pubmed/22564823
https://identifiers.org/pubmed/22771695
https://identifiers.org/pubmed/22399755
https://identifiers.org/pubmed/9872457
https://identifiers.org/pubmed/21673720
https://identifiers.org/pubmed/11585624
https://identifiers.org/pubmed/16295699
https://identifiers.org/pubmed/16504406
https://identifiers.org/pubmed/12861073
https://identifiers.org/pubmed/19932745
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