SPARQL | HTML5 RDFa and Microdata document
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http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
http://purl.obolibrary.org/obo/CL_0000540
http://purl.obolibrary.org/obo/CL_0002327
http://purl.obolibrary.org/obo/CL_0000169
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP3529_r134312
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/CL_0000540
http://purl.obolibrary.org/obo/PW_0000355
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://purl.obolibrary.org/obo/CL_0000169
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://purl.obolibrary.org/obo/CL_0002327
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000355
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3529&oldid=134312
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http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP3529_r134312
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP3529
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
Zinc is a transition metal and catalytic cofactor involved in many biological processes such as proliferation, development and differentiation, regulation of DNA synthesis, genomic stability, cell activation, RNA transcription, immune function. Zinc homeostasis in cells is ensured by various protein families including zinc transporters, zinc-binding proteins (Metallothioneins, MTs), transcription factors (MTF1-2). ZnT (1-10) transporters are responsible of zinc efflux and are assigned to the SLC30A family while ZIP (1-14) transporters are responsible for the influx of zinc into the cytoplasm and are assigned to the SLC39A family. Zn2+ enters into the cell by the ZIP transporters, and once inside the cell is available to bind metalloproteins (MT) which deliver to ZnT, or the zinc can bind directly to ZnTs and then deliver in the organelles / vesicles or lead outside the cell. Elevated zinc levels have been reported in different tumor tissue, such as breast and lung cancer.
http://purl.org/dc/terms/identifier http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/22057392
https://identifiers.org/pubmed/22289350
https://identifiers.org/pubmed/11831458
https://identifiers.org/pubmed/17344318
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