SPARQL | HTML5 RDFa and Microdata document
http://rdf.wikipathways.org/Pathway/WP3679_r128772/Complex/bcc43
http://rdf.wikipathways.org/Pathway/WP3679_r128772/Complex/f4f1f
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http://rdf.wikipathways.org/Pathway/WP3679_r128772/ComplexBinding/f4f1f
http://rdf.wikipathways.org/Pathway/WP3679_r128772/WP/Interaction/id1abd0d9f
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http://purl.obolibrary.org/obo/CL_0000118
http://purl.obolibrary.org/obo/CL_0000598
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http://purl.obolibrary.org/obo/DOID_1116
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http://purl.obolibrary.org/obo/PW_0000003
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http://purl.obolibrary.org/obo/CL_0000598
http://purl.obolibrary.org/obo/DOID_1116
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http://purl.obolibrary.org/obo/NCBITaxon_9606
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http://www.wikipathways.org/instance/WP3679_r128772
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP3679
http://purl.org/dc/elements/1.1/source
http://purl.org/dc/elements/1.1/title
Cell-type dependent selectivity of CCK2R signaling
http://purl.org/dc/terms/description
This pathway is based on Figure 7 of "Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal Parvalbumin-Positive Fast-Spiking Basket Cells."(See Bibliography).The neuropeptide cholecystokinin (CCK) acts through its receptor CCK2R to achieve largely different functions in different types of cells. CCK, CCK2R, and CB1R have all been known to have substantial effects on anxiety and other mood disorders, and the PV+ interneurons have also been shown to be involved i na variety of cognitive functions. However, In PV+ basket cells and CCK+ basket cells, the CCK2 receptor uses different pathways to exert different effects on the two types of basket cells. For CCK+ basket cells, CCK2 receptors in neighboring pyramidal cells act through the Gq pathway to form endocannabinoids, which, through the cannabinoid receptor type 1 on the CCK+ basket cell, inhibit the release of the neurotransmitter GABA. In contrast, for PV+ basket cells, CCK2 receptors act through the pertussin-toxin sensitive Gi pathway to regulate the intracellular Ca2+ through ryanodine receptors. This pathway ultimately leads to activation of a non-selective cationic conductance to depolarize the PV+ basket cells.
http://purl.org/dc/terms/identifier
http://purl.org/dc/terms/references
https://identifiers.org/pubmed/21795548
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/21795548
https://identifiers.org/pubmed/21173082
https://identifiers.org/chebi/CHEBI:42638
https://identifiers.org/chebi/CHEBI:67197
https://identifiers.org/chemspider/16736002
https://identifiers.org/chemspider/4209
https://identifiers.org/ensembl/ENSG00000004468
https://identifiers.org/ensembl/ENSG00000110148
https://identifiers.org/ensembl/ENSG00000118432
https://identifiers.org/ensembl/ENSG00000127955
https://identifiers.org/ensembl/ENSG00000134780
https://identifiers.org/ensembl/ENSG00000144935
https://identifiers.org/ensembl/ENSG00000196218
https://identifiers.org/ensembl/ENSG00000198626
https://identifiers.org/ensembl/ENSG00000198838
https://identifiers.org/pubchem.compound/122130
https://identifiers.org/pubchem.compound/123847
https://identifiers.org/pubchem.compound/3081323
https://identifiers.org/pubmed/21795548
https://identifiers.org/wikidata/Q27089044
https://identifiers.org/wikidata/Q4596857
https://identifiers.org/wikipathways/WP3679
https://identifiers.org/ensembl/ENSG00000150995
https://identifiers.org/ensembl/ENSG00000156052
https://identifiers.org/ensembl/ENSG00000182621
https://identifiers.org/ensembl/ENSG00000187094
https://identifiers.org/chebi/CHEBI:18035
https://identifiers.org/chebi/CHEBI:29101
https://identifiers.org/chebi/CHEBI:29108
https://identifiers.org/chemspider/116