SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/hmdb/HMDB0000058 https://identifiers.org/hmdb/HMDB0000112 https://identifiers.org/hmdb/HMDB0000148 https://identifiers.org/hmdb/HMDB0000464 https://identifiers.org/hmdb/HMDB0000538 https://identifiers.org/hmdb/HMDB0001043 https://identifiers.org/ensembl/ENSG00000005249 https://identifiers.org/ensembl/ENSG00000108946 https://identifiers.org/ensembl/ENSG00000188191 https://identifiers.org/ensembl/ENSG00000188822 https://identifiers.org/hmdb/HMDB0004666 https://identifiers.org/hmdb/HMDB0060501 https://identifiers.org/ensembl/ENSG00000106546 https://identifiers.org/ensembl/ENSG00000128271 https://identifiers.org/ensembl/ENSG00000140465 https://identifiers.org/ensembl/ENSG00000160868 https://identifiers.org/hmdb/HMDB0004080 https://identifiers.org/uniprot/O15264 https://identifiers.org/uniprot/P27361 https://identifiers.org/uniprot/P28482 https://identifiers.org/uniprot/P45983 https://identifiers.org/uniprot/P45984 https://identifiers.org/uniprot/P53778 https://identifiers.org/uniprot/P53779 https://identifiers.org/uniprot/Q15759 https://identifiers.org/uniprot/Q16539 https://identifiers.org/ec-code/2.7.11.24 https://identifiers.org/hmdb/HMDB0041865 https://identifiers.org/hmdb/HMDB0060906 https://identifiers.org/ensembl/ENSG00000138109 https://identifiers.org/chebi/CHEBI:61232 https://identifiers.org/ensembl/ENSG00000072062 https://identifiers.org/ensembl/ENSG00000121281 https://identifiers.org/ensembl/ENSG00000142875 https://identifiers.org/ensembl/ENSG00000164742 https://identifiers.org/ensembl/ENSG00000165059 http://rdf.wikipathways.org/Pathway/WP3869_r118463/Complex/a31a3 http://rdf.wikipathways.org/Pathway/WP3869_r118463/Complex/a352c http://rdf.wikipathways.org/Pathway/WP3869_r118463/Complex/f92cd http://rdf.wikipathways.org/Pathway/WP3869_r118463/ComplexBinding/a31a3 http://rdf.wikipathways.org/Pathway/WP3869_r118463/ComplexBinding/a352c http://rdf.wikipathways.org/Pathway/WP3869_r118463/ComplexBinding/f92cd http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/ea2d8 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id13dcbab6 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id2bcd6568 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id2eb7c766 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id2fb5428e http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id3a386560 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id566b671e http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id5d2c054a http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id635b63f9 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id64bb62e9 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id66a29503 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id6a3d2168 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id7a2c5244 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id7f653755 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id88127f88 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id8f2539a1 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id955803ea http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/id9b949cac http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/ida09820b1 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idaf0d839a http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idb26069eb http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idb26224c6 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idcb468db4 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idcbff8645 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idce1677fd http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/iddb9b6c69 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/iddf6bc193 http://rdf.wikipathways.org/Pathway/WP3869_r118463/WP/Interaction/idfbfc0fd https://identifiers.org/wikipathways/WP3869_r118463
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP3869_r118463
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP3869
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
Cannabinoid receptor signaling
http://purl.org/dc/terms/description
Endogenous cannabinoid receptors belong to the endocannabinoid system and are located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. The endocannabinoid system is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis. Two primary endocannabinoid receptors have been identified: CNR1 and CNR2. CNR1 is found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC (tetrahydrocannabinol). One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD (cannabidiol). 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.
Source: https://en.wikipedia.org/wiki/Endocannabinoid_system
Not all MAPK subtypes are relevant for this pathway. The relevant types have been separately added on the right side of the pathway.
Source: Howlett A.C. Cannabinoid Receptor Signaling. In: Pertwee R.G. (eds) Cannabinoids. Handbook of Experimental Pharmacology, vol 168. Springer, Berlin, Heidelberg, 2005
http://purl.org/dc/terms/identifier http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/26187180
https://identifiers.org/pubmed/27106177
https://identifiers.org/pubmed/26218440
https://identifiers.org/pubmed/21704641
https://identifiers.org/pubmed/16672367
https://identifiers.org/pubmed/23108542
http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
http://purl.obolibrary.org/obo/CL_0000540
http://purl.obolibrary.org/obo/CL_0000738
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP3869_r118463
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/PW_0001229
http://vocabularies.wikipathways.org/wp#Curation:Diseases
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://purl.obolibrary.org/obo/PW_0001163
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://purl.obolibrary.org/obo/CL_0000540
http://purl.obolibrary.org/obo/CL_0000738
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0001229
http://purl.obolibrary.org/obo/PW_0001163
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3869&oldid=118463
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3869&oldid=118463
https://identifiers.org/ensembl/ENSG00000117480 https://identifiers.org/ensembl/ENSG00000165841 https://identifiers.org/chebi/CHEBI:133049 https://identifiers.org/chebi/CHEBI:133052 https://identifiers.org/chebi/CHEBI:133053 https://identifiers.org/chebi/CHEBI:133055 https://identifiers.org/chebi/CHEBI:133058 https://identifiers.org/chebi/CHEBI:133059 https://identifiers.org/ensembl/ENSG00000164535 https://identifiers.org/wikipathways/WP3869 https://identifiers.org/ensembl/ENSG00000118432 https://identifiers.org/ensembl/ENSG00000134780 https://identifiers.org/ensembl/ENSG00000161048 https://identifiers.org/chebi/CHEBI:133056 https://identifiers.org/chebi/CHEBI:133062 https://identifiers.org/chebi/CHEBI:69478 https://identifiers.org/chebi/CHEBI:77273 https://identifiers.org/ena.embl/ENSG00000114302