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Clear cell renal cell carcinoma pathways
http://purl.org/dc/terms/description
Inactivation of VHL due to mutation or DNA methylation is an early event in ccRCC that leads to accumulation of the transcription factor HIF-α, which dimerizes with HIF-β and translocates to the nucleus. The resulting HIF-α–HIF-β-induced up-regulation of downstream genes promotes cell proliferation, glucose uptake, glycolysis, and angiogenesis.
Mutations in chromatin remodelers and histone modifiers including PBRM1, SETD2, BAP1 and KDM5C lead to global abnormal gene expression patterns, and deficiency in DNA repair, which contributes to genomic instability.
Activation of PI3K–mTOR signaling promotes cell proliferation and tumor aggression, and increases translation of HIF-α, leading to enhanced HIF-α-mediated gene expression. The proposed development pattern of ccRCC is based on tumor evolution analyses and current understanding of genomic variation.
Description adapted from "Precision medicine from the renal cancer genome", Riazalhosseini and Lathrop.
Additional sources of information:
mTORC1 complex is based on [https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin#mTORC1 Wikipedia]. PDGFB and TGFB as targets of HIF1A based on [http://www.genome.jp/kegg-bin/show_pathway?hsa05211 KEGG].
Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/27694978
https://identifiers.org/pubmed/25514926
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/28329682
https://identifiers.org/pubmed/27694978
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