SPARQL | HTML5 RDFa and Microdata document
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4255_r138079
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4255_r138079
  • http://rdf.wikipathways.org/Pathway/WP4255_r138079/WP/Interaction/id531ac1cd
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4255_r138079
  • http://rdf.wikipathways.org/Pathway/WP4255_r138079/WP/Interaction/id560a2d23
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4255_r138079
  • http://rdf.wikipathways.org/Pathway/WP4255_r138079/WP/Interaction/idb6bdd1ca
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4255_r138079
  • http://rdf.wikipathways.org/Pathway/WP4255_r138079/WP/Interaction/idbdba7f13
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4255_r138079
  • https://identifiers.org/wikipathways/WP4255_r138079
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://www.w3.org/2004/02/skos/core#Collection
      • http://vocabularies.wikipathways.org/wp#Pathway
    • http://xmlns.com/foaf/0.1/page
      • http://www.wikipathways.org/instance/WP4255_r138079
    • http://purl.org/dc/elements/1.1/identifier
      • https://identifiers.org/wikipathways/WP4255
    • http://purl.org/dc/elements/1.1/source
      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • Non-small cell lung cancer
    • http://purl.org/dc/terms/description
      • Non-small cell lung cancer (NSCLC) represents 85% of lung cancer and is defined as any type of epithelial lung cancer that is _not_ small cell carcinoma, including squamous cell (SCC), adeno (AC) and large-cell carcinoma. Mutations in NSCLC: KRAS (mutated in ~29% of NSCLC patients) inactivates its GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Mutations or overexpression of EGFR (~22% of NSCLC patients) leads to increased proliferation. The abnormal fusion of EML4-ALK (~5% of NSCLC patients) leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Inactivating mutation of p53 (~50% of NSCLC patients) leads to reduced apoptosis and proliferation. The protein encoded by the p16INK4a, CDKN2A, inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. p16INK4a is mutated in ~12% of NSCLC patients, which leads to a loss of this inhibitory effect. RARB is a nuclear retinoic acid receptor whose function is often lost in NSCLC, leading to a loss of cell growth control. This pathway was developed based on [KEGG](https://www.kegg.jp/dbget-bin/www_bget?pathway+map05223). Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
    • http://purl.org/dc/terms/identifier
      • WP4255
    • http://purl.org/dc/terms/references
      • https://identifiers.org/pubmed/28572459
      • https://identifiers.org/pubmed/25514926
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/17328863
      • https://identifiers.org/pubmed/28572459
      • https://identifiers.org/pubmed/20418096
      • https://identifiers.org/pubmed/25514926
      • https://identifiers.org/pubmed/23322901
    • http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
      • http://purl.obolibrary.org/obo/CL_0002328
    • http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
      • http://purl.obolibrary.org/obo/DOID_1749
      • http://purl.obolibrary.org/obo/DOID_4556
      • http://purl.obolibrary.org/obo/DOID_1324
      • http://purl.obolibrary.org/obo/DOID_3910
      • http://purl.obolibrary.org/obo/DOID_3908
    • http://vocabularies.wikipathways.org/wp#isAbout
      • http://rdf.wikipathways.org/Pathway/WP4255_r138079
    • http://vocabularies.wikipathways.org/wp#ontologyTag
      • http://purl.obolibrary.org/obo/PW_0000605
      • http://vocabularies.wikipathways.org/wp#Curation:CPTAC
      • http://vocabularies.wikipathways.org/wp#Curation:Diseases
      • http://purl.obolibrary.org/obo/CL_0002328
      • http://purl.obolibrary.org/obo/PW_0000703
      • http://purl.obolibrary.org/obo/DOID_1749
      • http://purl.obolibrary.org/obo/PW_0000013
      • http://purl.obolibrary.org/obo/DOID_4556
      • http://purl.obolibrary.org/obo/DOID_1324
      • http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
      • http://purl.obolibrary.org/obo/DOID_3908
      • http://purl.obolibrary.org/obo/DOID_3910
    • http://vocabularies.wikipathways.org/wp#organism
      • http://purl.obolibrary.org/obo/NCBITaxon_9606
    • http://vocabularies.wikipathways.org/wp#organismName
      • Homo sapiens
    • http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
      • http://purl.obolibrary.org/obo/PW_0000703
      • http://purl.obolibrary.org/obo/PW_0000013
      • http://purl.obolibrary.org/obo/PW_0000605
    • http://xmlns.com/foaf/0.1/img
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4255&oldid=138079
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4255&oldid=138079