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    • http://vocabularies.wikipathways.org/wp#Pathway
  • http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
    • http://purl.obolibrary.org/obo/CL_0000584
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  • http://vocabularies.wikipathways.org/wp#organismName
    • Homo sapiens
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    • http://purl.obolibrary.org/obo/PW_0000724
  • http://xmlns.com/foaf/0.1/img
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    • WikiPathways
  • http://purl.org/dc/elements/1.1/title
    • Statin inhibition of cholesterol production
  • http://purl.org/dc/terms/description
    • Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [PharmGKB](https://www.pharmgkb.org/pathway/PA2031) and [Wikipedia](http://en.wikipedia.org/wiki/Statin) Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP430).
  • http://purl.org/dc/terms/identifier
    • WP430
  • http://purl.org/dc/terms/references
    • https://identifiers.org/pubmed/10770267
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    • https://identifiers.org/pubmed/9106493
    • https://identifiers.org/pubmed/10770267