SPARQL | HTML5 RDFa and Microdata document
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http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP4466_r137054
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP4466
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
Oxidative stress and redox pathway
http://purl.org/dc/terms/description
This pathway represents biology relevant to glutathione, including biosynthesis, metabolism, redox cycle, uptake, glutathionylation and acivicin inhibition.
Glutathione is an antioxidant that is synthesized in eukaryotes from L-cysteine, L-glutamic acid, and glycine in a two-step process involving gamma-glutamylcysteine synthetase and glutathione synthetase. Glutathione prevents cellular damage by acting as an electron donor to neutralize reactive oxygen species. Reactive glutathione is produced, which then reacts with another reactive glutathione molecule to produce glutathione disulfide, GSSG.
It was based partly on [WP164](https://www.wikipathways.org/pathways/WP164.html) and [WP1770](https://www.wikipathways.org/pathways/WP1770.html), with information added from literature.
This pathway was created as a part of [Mendiola et cl](https://www.nature.com/articles/s41590-020-0654-0), pictured in fig 5.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/32284594
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/15988009
https://identifiers.org/pubmed/27579494
https://identifiers.org/pubmed/32284594
https://identifiers.org/pubmed/21037289
https://identifiers.org/pubmed/23770340
https://identifiers.org/pubmed/24287781
https://identifiers.org/pubmed/24647116
https://identifiers.org/pubmed/18786560
https://identifiers.org/pubmed/18818725
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP4466_r137054
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/PW_0002623
http://purl.obolibrary.org/obo/PW_0001277
http://purl.obolibrary.org/obo/PW_0000134
http://purl.obolibrary.org/obo/PW_0000002
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_10090
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0002623
http://purl.obolibrary.org/obo/PW_0001277
http://purl.obolibrary.org/obo/PW_0000134
http://purl.obolibrary.org/obo/PW_0000002
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4466&oldid=137054
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