Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung.
Genes altered in small cell lung carcinoma:
1. TP53 is mutated in 70-90% of SCLCs.
2. RB1 is inactivated in most SCLCs.
3. PTEN is mutated in 2-10% of SCLCs.
4. MYC amplifications and amplification of MYC family members is found in 30% of SCLCs.
5. FHIT protein expression is lost due to loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs.
This description was adapted from [Wikipedia](https://en.wikipedia.org/wiki/Small-cell_carcinoma).
Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.