SPARQL | HTML5 RDFa and Microdata document
  • http://rdf.wikipathways.org/Pathway/WP4876_r134900/Complex/b6589
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      • https://identifiers.org/wikipathways/WP4876_r134900
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4876_r134900
  • https://identifiers.org/wikipathways/WP4876_r134900
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://www.w3.org/2004/02/skos/core#Collection
      • http://vocabularies.wikipathways.org/wp#Pathway
    • http://xmlns.com/foaf/0.1/page
      • http://www.wikipathways.org/instance/WP4876_r134900
    • http://purl.org/dc/elements/1.1/identifier
      • https://identifiers.org/wikipathways/WP4876
    • http://purl.org/dc/elements/1.1/source
      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • Activation of NLRP3 inflammasome by SARS-CoV-2
    • http://purl.org/dc/terms/description
      • Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome. The activation occurs at two points. First, by ubiquinating NF-kB (p105) to stimulate its proteolytic processing into mature NF-kB (p50), which can then go on to promote the transcription of pro-IL-1B together with RELA (p65). And second, by ubiquitinating ASC (PYCARD) in the NLRP3 inflammasome, which leads to its degradtion and the activation of caspase-1 (CASP1) that goes on to catalyze the production of mature IL-1B, leading to a cytokine storm. While Orf3a of SARS-CoV-2 only has 72.7% sequence identity with that of SARS-CoV, the TRAF3 binding motif PxQxS is 100% conserved (https://alexanderpico.github.io/SARS-CoV-2_Alignments/#Orf3a). Chloroquine, a multi-functional antiviral, decreases the production of IL-1B by affecting "the processing of primary transcripts in the nucleus, the transport of processed mRNA to the cytosol, and the degradation of mRNA." (Jang 2006)
    • http://purl.org/dc/terms/identifier
      • WP4876
    • http://purl.org/dc/terms/references
      • https://identifiers.org/pubmed/31034780
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/31034780
    • http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
      • http://purl.obolibrary.org/obo/DOID_934
      • http://purl.obolibrary.org/obo/DOID_2945
      • http://purl.obolibrary.org/obo/DOID_0080600
    • http://vocabularies.wikipathways.org/wp#isAbout
      • http://rdf.wikipathways.org/Pathway/WP4876_r134900
    • http://vocabularies.wikipathways.org/wp#ontologyTag
      • http://purl.obolibrary.org/obo/DOID_0080600
      • http://purl.obolibrary.org/obo/DOID_934
      • http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
      • http://vocabularies.wikipathways.org/wp#Curation:COVID19
      • http://purl.obolibrary.org/obo/DOID_2945
      • http://purl.obolibrary.org/obo/PW_0000004
      • http://purl.obolibrary.org/obo/PW_0000883
    • http://vocabularies.wikipathways.org/wp#organism
      • http://purl.obolibrary.org/obo/NCBITaxon_9606
    • http://vocabularies.wikipathways.org/wp#organismName
      • Homo sapiens
    • http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
      • http://purl.obolibrary.org/obo/PW_0000004
      • http://purl.obolibrary.org/obo/PW_0000883
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      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4876&oldid=134900
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4876&oldid=134900
  • https://identifiers.org/ensembl/ENSG00000109320
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      • https://identifiers.org/wikipathways/WP4876_r134900
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      • https://identifiers.org/wikipathways/WP4876_r134900
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      • https://identifiers.org/wikipathways/WP4876_r134900
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    • http://purl.org/pav/hasVersion
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  • https://identifiers.org/pubmed/31034780
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      • https://identifiers.org/wikipathways/WP4876_r134900
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  • https://identifiers.org/ensembl/ENSG00000173039
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4876_r134900
  • https://identifiers.org/wikipathways/WP5257
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4876_r134900