SPARQL | HTML5 RDFa and Microdata document
  • https://identifiers.org/pubmed/31226023
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • https://identifiers.org/ncbigene/5594
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • https://identifiers.org/ncbigene/6300
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/Complex/a2e0f
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • https://identifiers.org/ensembl/ENSG00000142089
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/ac5f2
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/ad2dd
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/c78d1
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/cdc9a
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/e88fb
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/ea117
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/f1e34
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/idc72f872e
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • http://rdf.wikipathways.org/Pathway/WP4877_r124642/WP/Interaction/ide8866e40
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • https://identifiers.org/wikidata/Q89457519
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP4877_r124642
  • https://identifiers.org/wikipathways/WP4877
    • http://purl.org/pav/hasVersion
      • https://identifiers.org/wikipathways/WP4877_r124642
  • https://identifiers.org/wikipathways/WP4877_r124642
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://vocabularies.wikipathways.org/wp#Pathway
      • http://www.w3.org/2004/02/skos/core#Collection
    • http://xmlns.com/foaf/0.1/page
      • http://www.wikipathways.org/instance/WP4877_r124642
    • http://purl.org/dc/elements/1.1/identifier
      • https://identifiers.org/wikipathways/WP4877
    • http://purl.org/dc/elements/1.1/source
      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • Host-pathogen interaction of human coronaviruses - MAPK signaling
    • http://purl.org/dc/terms/description
      • This pathway describes the activation of the human MAPK signaling system during human coronavirus infection, per Fung and Liu, Figure 7 [10.1146/annurev-micro-020518-115759]. The MAPK signaling system regulates response to different environmental stimuli, e.g. inflammation due to infection. Its downstream effects include regulation of cell cycle, apoptosis, differentiation and immune response. During coronavirus infection, three MAPK signaling pathways were studied and described. The p38 pathway (MAPK11 - MAPK14) leads to stimulation of apoptosis via CHOP (DDIT3) while the ERK pathway (MAPK1 and MAPK3) counteracts apoptosis stimulation and supports cell survival by stimulating ATF2 and FOS. The JNK pathway (MAPK 8 - MAPK10) inhibits cell survival protein BCL2, thus stimulating apoptosis but also stimulating the AP1 complex that leads to the production of effectors to fight the infection. The interplay of apoptosis stimulation and cell survival is not yet fully understood in SARS-CoV-2 infection.
    • http://purl.org/dc/terms/identifier
      • WP4877
    • http://purl.org/dc/terms/references
      • https://identifiers.org/pubmed/31226023
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/31226023
      • https://doi.org/10.1101/2020.03.15.20033472
    • http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
      • http://purl.obolibrary.org/obo/DOID_2945
      • http://purl.obolibrary.org/obo/DOID_0080600
      • http://purl.obolibrary.org/obo/DOID_934
    • http://vocabularies.wikipathways.org/wp#isAbout
      • http://rdf.wikipathways.org/Pathway/WP4877_r124642
    • http://vocabularies.wikipathways.org/wp#ontologyTag
      • http://purl.obolibrary.org/obo/PW_0000198
      • http://purl.obolibrary.org/obo/DOID_2945
      • http://vocabularies.wikipathways.org/wp#Curation:COVID19
      • http://purl.obolibrary.org/obo/DOID_0080600
      • http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
      • http://purl.obolibrary.org/obo/PW_0000003
      • http://purl.obolibrary.org/obo/DOID_934
    • http://vocabularies.wikipathways.org/wp#organism
      • http://purl.obolibrary.org/obo/NCBITaxon_9606
    • http://vocabularies.wikipathways.org/wp#organismName
      • Homo sapiens
    • http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
      • http://purl.obolibrary.org/obo/PW_0000003
      • http://purl.obolibrary.org/obo/PW_0000198
    • http://xmlns.com/foaf/0.1/img
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4877&oldid=124642
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