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      • Pre-synaptic neurons release glutamate, which acts on various receptors (kainate, metabotropic, AMPA and NMDA), thereby regulating LTP, LDP, neuronal survival and proliferation. Glutamate retro-signaling negatively regulates its exocytotic release. The remainder of glutamate is taken up by astrocytes through EAAT1-4. Glutamine is generated from blood-derived glucose, transported to pre-synaptic neurons and converted into glutamate. Alternatively, glucose is converted into D-serine, which functions as co-agonist for NMDARs and is broken down by DAAO. CNS inflammation induces M1 and M2 microglia, which modulate neuronal and astrocyte function.
    • http://purl.org/dc/terms/identifier
      • WP5083
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/23087426
      • https://identifiers.org/pubmed/11403878
      • https://identifiers.org/pubmed/23853735
      • https://identifiers.org/pubmed/23630460
      • https://identifiers.org/pubmed/7615345
      • https://identifiers.org/pubmed/22287959
      • https://identifiers.org/pubmed/21779718
      • https://identifiers.org/pubmed/33239064
      • https://identifiers.org/pubmed/33510058
      • https://identifiers.org/pubmed/33511116
      • https://identifiers.org/pubmed/29018191
      • https://identifiers.org/pubmed/28603493
      • https://identifiers.org/pubmed/27443914
      • https://identifiers.org/pubmed/19909229
      • https://identifiers.org/pubmed/27187935
      • https://identifiers.org/pubmed/33050345
      • https://identifiers.org/pubmed/33061891
      • https://identifiers.org/pubmed/30459650
      • https://identifiers.org/pubmed/29898976
      • https://identifiers.org/pubmed/25078115
      • https://identifiers.org/pubmed/17440456
      • https://identifiers.org/pubmed/25598354
      • https://identifiers.org/pubmed/15291819
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      • http://purl.obolibrary.org/obo/CL_0000129
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      • http://vocabularies.wikipathways.org/wp#Curation:ONTOX
      • http://purl.obolibrary.org/obo/PW_0000059
      • http://purl.obolibrary.org/obo/CL_0000540
      • http://purl.obolibrary.org/obo/CL_0000125
      • http://purl.obolibrary.org/obo/CL_0000127
      • http://purl.obolibrary.org/obo/CL_0000129
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      • http://purl.obolibrary.org/obo/NCBITaxon_9606
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      • Homo sapiens
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