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http://purl.obolibrary.org/obo/CL_0000125
http://purl.obolibrary.org/obo/CL_0000127
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http://purl.obolibrary.org/obo/PW_0000059
http://purl.obolibrary.org/obo/PW_0000240
http://purl.obolibrary.org/obo/PW_0000818
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http://purl.org/dc/elements/1.1/title
Neuroinflammation and glutamatergic signaling
http://purl.org/dc/terms/description
Pre-synaptic neurons release glutamate, which acts on various receptors (kainate, metabotropic, AMPA and NMDA), thereby regulating LTP, LDP, neuronal survival and proliferation. Glutamate retro-signaling negatively regulates its exocytotic release. The remainder of glutamate is taken up by astrocytes through EAAT1-4. Glutamine is generated from blood-derived glucose, transported to pre-synaptic neurons and converted into glutamate. Alternatively, glucose is converted into D-serine, which functions as co-agonist for NMDARs and is broken down by DAAO. CNS inflammation induces M1 and M2 microglia, which modulate neuronal and astrocyte function.
The relation between neuroinflammation and glutamatergic signaling
http://purl.org/dc/terms/identifier
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