SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/chebi/CHEBI:15361 https://identifiers.org/chebi/CHEBI:17050 https://identifiers.org/chebi/CHEBI:17138 https://identifiers.org/chebi/CHEBI:24344 https://identifiers.org/chebi/CHEBI:4170 https://identifiers.org/chebi/CHEBI:89363 https://identifiers.org/chebi/CHEBI:18021 https://identifiers.org/chebi/CHEBI:24996 https://identifiers.org/ncbigene/2475 https://identifiers.org/ensembl/ENSG00000159399 https://identifiers.org/chebi/CHEBI:32966 https://identifiers.org/chebi/CHEBI:4167 https://identifiers.org/ensembl/ENSG00000112715 https://identifiers.org/ensembl/ENSG00000117394 https://identifiers.org/ensembl/ENSG00000121879 https://identifiers.org/ensembl/ENSG00000136997 https://identifiers.org/hgnc.symbol/FBP1 https://identifiers.org/ncbigene/207 https://identifiers.org/ncbigene/2308 https://identifiers.org/ncbigene/2538 https://identifiers.org/ncbigene/3091 https://identifiers.org/ncbigene/3939 https://identifiers.org/ncbigene/5223 https://identifiers.org/ncbigene/5230 https://identifiers.org/ncbigene/7874 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ec223 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id145f76be http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id242a7a14 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id25d9d322 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id356e003f http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id4137c26f http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id42ad3a5d http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id431f798b http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id4394d9f8 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id478f171b http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id48664eb4 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id49634da http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id4a21908d http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id4c738f7e http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id581f8ac9 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id58af8d42 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id61e01cb3 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id63384f0d http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id66afe83a http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id6fdf5fd4 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id7d485c38 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id80aeae06 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id823acbbd http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id8ec4ad54 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id90f1ae6d http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id91684b77 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id91c5a538 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/id92d66332 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ida41adcbe http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idac23cbf3 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idac528ce http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idb573a17b http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idbecdfda http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idc8d05b6f http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idd0b23cb0 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idd19bc614 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idd414123e http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idd471abf1 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idd62e7732 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/iddaf4e1c6 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/iddc7d8937 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/iddeaa8afe http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ide23d1db http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ide5cafcd2 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ide7664178 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ide8a854e http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ide94d83f9 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/ideaa5b55b http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idf26117c4 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idf42cce1f http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idfab8b1f7 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idfd935ea5 http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idfdbe3a7f http://rdf.wikipathways.org/Pathway/WP5216_r126981/WP/Interaction/idfe89f049 https://doi.org/10.3390/IJMS22126173 https://identifiers.org/chebi/CHEBI:61527 https://identifiers.org/ncbigene/51547 https://identifiers.org/ncbigene/51633 https://identifiers.org/wikipathways/WP5216 https://identifiers.org/wikipathways/WP5216_r126981
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP5216_r126981
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP5216
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
Warburg effect modulated by deubiquitinating enzymes and their substrates
http://purl.org/dc/terms/description
Even in the presence of oxygen, cancer cells convert glucose to lactate as their main source for energy production, instead of using the citric acid cycle and oxidative phosphorylation. This process is called the Warburg effect. This pathway shows the effects deubiquitinating enzymes (DUBs) and their substrates have. DUBs free proteins of their ubiquitin chain, so that the proteins can resume their function in the cells rather than be degraded by the ubiquitin-proteasome system (UPS).
The deubiquitination of VHL via OTUD6B (part of a DUB subfamily) represses HIF-1α, whereas the direct deubiquitination of HIF-1a via DUBs leads to the increased expression of GLUT1 and VEGF. The transcription factor c-Myc helps regulate gene expression involved in the glucose metabolism (e.g., GLUT1, HK2, LDHA) and is stabilised by ubiquitin-specific proteases. The PI3K/Akt pathway is also upregulated by deubiquitination of VEGF and Akt. This entails cell growth and apoptosis regulation, as well as promoted glucose transport to cancer cells and activating mTor, which improves glycolysis.
It is shown in this pathway, how deubiquitinating enzymes play an important role in stabilizing different proteins, acting as oncoproteins and tumor suppressors equally.
This pathway is based on figure 3 featured in “Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect” by So-Hee Kim and Kwang-Hyun Baek.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://doi.org/10.3390/IJMS22126173
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/23216836
https://doi.org/10.3390/IJMS22126173
https://identifiers.org/pubmed/21591214
https://identifiers.org/pubmed/30742905
http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
http://purl.obolibrary.org/obo/DOID_162
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP5216_r126981
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/DOID_162
http://vocabularies.wikipathways.org/wp#Curation:CPTAC
http://purl.obolibrary.org/obo/PW_0000640
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000640
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5216&oldid=126981
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5216&oldid=126981
https://identifiers.org/ensembl/ENSG00000134086 https://identifiers.org/ncbigene/11338 https://identifiers.org/ensembl/ENSG00000128052 https://identifiers.org/ncbigene/10869 https://identifiers.org/ncbigene/56957 https://identifiers.org/ncbigene/57646 https://identifiers.org/ncbigene/57695 https://identifiers.org/ncbigene/78990 https://identifiers.org/ncbigene/84101