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Estradiol regulation in porto-sinusoidal vascular disease
http://purl.org/dc/terms/description
Porto-sinusoidal vascular disease (PSVD) is a rare disease (Schouten et al., 2015), affecting less than 1 in 2000 citizens (European standard) (Griffon et al., 2016). It is characterized by signs of presinusoidal portal hypertension without cirrhosis, where the cause of the hypertension is unknown (Lee et al., 2016; Schouten et al., 2011). Based on that what is known about the etiology of PSVD, its development can be categorized into five groups: immunological disorders, chronic infections, exposure to medications or toxins, prothrombic conditions, and genetic predisposition (Schouten et al., 2015). In practice, the disease has multiple contributing factors (Siramolpiwat et al., 2016).
This pathway describes a mutation in the KCNN3 gene that is hypothesized to result in genetic predisposition to PSVD (Koot et al., 2016). PSVD has also been referred as idiopathic non-cirrhotic portal hypertension (INCPH), hepatoportal sclerosis, incomplete septal cirrhosis, obliterative portal venopathy, partial nodular transformation, non-cirrhotic portal fibrosis, nodular regenerative hyperplasia (NRH), and idiopathic portal hypertension (Schouten et al., 2015; Siramolpiwat et al., 2016; Besmond et al., 2017).
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/26563701
https://identifiers.org/pubmed/26025214
https://identifiers.org/pubmed/27484923
https://identifiers.org/pubmed/21574171
https://identifiers.org/pubmed/28792652
https://identifiers.org/pubmed/26658685
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/16443824
https://identifiers.org/pubmed/8781233
https://identifiers.org/pubmed/27484923
https://identifiers.org/pubmed/28792652
https://identifiers.org/pubmed/12805243
https://identifiers.org/pubmed/12659870
https://identifiers.org/pubmed/26025214
https://identifiers.org/pubmed/26658685
https://identifiers.org/pubmed/26563701
https://identifiers.org/pubmed/20349244
https://identifiers.org/pubmed/29651007
https://identifiers.org/pubmed/20682843
https://identifiers.org/pubmed/20813245
https://identifiers.org/pubmed/33329039
https://identifiers.org/pubmed/21574171
https://identifiers.org/pubmed/28792652 https://identifiers.org/uniprot/P0DP23 https://identifiers.org/chebi/CHEBI:16469 https://identifiers.org/ensembl/ENSG00000143603 https://identifiers.org/pubchem.compound/16133797 https://identifiers.org/pubmed/21574171 https://identifiers.org/pubmed/26025214 https://identifiers.org/pubmed/26563701 https://identifiers.org/pubmed/27484923 https://identifiers.org/uniprot/P03372 https://identifiers.org/uniprot/P08047 https://identifiers.org/uniprot/Q02447 https://identifiers.org/uniprot/Q9UGI6 https://identifiers.org/wikipathways/WP5235 https://identifiers.org/chebi/CHEBI:29103 https://identifiers.org/chebi/CHEBI:29108