Duchenne Muscular Dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration and weakness due to the absence of dystrophin. Abnormal calcium handling is one of the key pathological features of DMD, which has been shown to contribute to muscle damage and impaired muscle contraction. This pathway shows how the absence of dystrophin can lead to reduced force generation due to the lack of calcium ions released from the sarcoplasmic reticulum during muscle contraction.
Abnormal calcium handling and its effects on muscle contraction in DMD