SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/uniprot/P29279 https://identifiers.org/uniprot/Q13485 https://identifiers.org/uniprot/P61981 https://identifiers.org/uniprot/Q9GZV5 https://identifiers.org/uniprot/P05121 https://identifiers.org/uniprot/Q03167 https://identifiers.org/pubmed/22923731 https://identifiers.org/pubmed/24727033 https://identifiers.org/pubmed/29286147 https://identifiers.org/uniprot/P01137 https://identifiers.org/uniprot/P36897 https://identifiers.org/uniprot/P37173 https://identifiers.org/uniprot/P84022 https://identifiers.org/uniprot/Q15796 https://identifiers.org/pubmed/28769795 https://identifiers.org/pubmed/33894227 https://identifiers.org/pubmed/35954181 https://identifiers.org/uniprot/P09486 https://identifiers.org/uniprot/Q15063 https://identifiers.org/wikidata/Q193825 https://identifiers.org/wikipathways/WP5382 https://identifiers.org/wikipathways/WP5382_r129730
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
http://purl.obolibrary.org/obo/CL_0002367
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP5382_r129730
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/CL_0002367
http://purl.obolibrary.org/obo/PW_0000490
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000490
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5382&oldid=129730
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5382&oldid=129730
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP5382_r129730
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP5382
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
Regulation of TGFβ/Smad Signaling Pathway in Trabecular Meshwork (TM) cells. In this pathway, TGF-β binds to the TGF-β-type II receptor, inducing the activation of the TGF-β-type-I receptor. This induces the phosphorylation of Smad2/3 proteins which form a complex with Smad4. The translocation of this complex to the nucleus is facilitated by the TAZ protein. Once in the nucleous, it binds to SBEs (Smad Binding Elements), promoting the transcription of TGF-beta-response genes. The inhibition of this translocation instead occurs when phosphorylated TAZ protein interacts with 14-3-3 protein preventing the formation of complex TAZ-Smad.
The translated ECM proteins are secreted by TM cells to the extracellular space.
This pathway is based on Figure 4 of the publication “Mutual regulation of the Hippo/Wnt/LPA/TGF-β signaling pathways and their roles in glaucoma (Review)” by Xin Wang, Guoli Huai, Hailian Wang, Yuande Liu, Ping Qi, Wei Shi, Jie Peng, Hongji Yang, Shaoping Deng, and Yi Wang.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/24727033
https://identifiers.org/pubmed/22923731
https://identifiers.org/pubmed/33894227
https://identifiers.org/pubmed/35954181
https://identifiers.org/pubmed/29286147
https://identifiers.org/pubmed/28769795
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/28769795
https://identifiers.org/pubmed/33894227
https://identifiers.org/pubmed/35954181
https://identifiers.org/pubmed/22923731
https://identifiers.org/pubmed/24727033
https://identifiers.org/pubmed/29286147
https://identifiers.org/pubmed/35300422
http://rdf.wikipathways.org/Pathway/WP5382_r129730/Complex/b19e7 http://rdf.wikipathways.org/Pathway/WP5382_r129730/Complex/ddc11 http://rdf.wikipathways.org/Pathway/WP5382_r129730/Complex/de9ab http://rdf.wikipathways.org/Pathway/WP5382_r129730/Complex/df776 http://rdf.wikipathways.org/Pathway/WP5382_r129730/ComplexBinding/b19e7 http://rdf.wikipathways.org/Pathway/WP5382_r129730/ComplexBinding/ddc11 http://rdf.wikipathways.org/Pathway/WP5382_r129730/ComplexBinding/de9ab http://rdf.wikipathways.org/Pathway/WP5382_r129730/ComplexBinding/df776 http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/b6200 http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/d13e3 http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/d7f3c http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/e8074 http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/fda4c http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/id1e336d19 http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/id867165d4 http://rdf.wikipathways.org/Pathway/WP5382_r129730/WP/Interaction/idec455bcc