SPARQL | HTML5 RDFa and Microdata document
  • https://identifiers.org/pubmed/26675719
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/pubmed/27314095
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/pubmed/29438108
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/uniprot/P40763
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/wikipathways/WP5428_r134737
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://vocabularies.wikipathways.org/wp#Pathway
      • http://www.w3.org/2004/02/skos/core#Collection
    • http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
      • http://purl.obolibrary.org/obo/CL_0000815
      • http://purl.obolibrary.org/obo/CL_0001050
      • http://purl.obolibrary.org/obo/CL_0001063
      • http://purl.obolibrary.org/obo/CL_0001064
    • http://vocabularies.wikipathways.org/wp#isAbout
      • http://rdf.wikipathways.org/Pathway/WP5428_r134737
    • http://vocabularies.wikipathways.org/wp#ontologyTag
      • http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
      • http://purl.obolibrary.org/obo/CL_0000815
      • http://purl.obolibrary.org/obo/CL_0001064
      • http://purl.obolibrary.org/obo/CL_0001050
      • http://purl.obolibrary.org/obo/CL_0001063
      • http://purl.obolibrary.org/obo/PW_0000605
      • http://purl.obolibrary.org/obo/PW_0000328
    • http://vocabularies.wikipathways.org/wp#organism
      • http://purl.obolibrary.org/obo/NCBITaxon_9606
    • http://vocabularies.wikipathways.org/wp#organismName
      • Homo sapiens
    • http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
      • http://purl.obolibrary.org/obo/PW_0000328
      • http://purl.obolibrary.org/obo/PW_0000605
    • http://xmlns.com/foaf/0.1/img
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5428&oldid=134737
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5428&oldid=134737
    • http://xmlns.com/foaf/0.1/page
      • http://www.wikipathways.org/instance/WP5428_r134737
    • http://purl.org/dc/elements/1.1/identifier
      • https://identifiers.org/wikipathways/WP5428
    • http://purl.org/dc/elements/1.1/source
      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • FGFR4 p.G388R signaling
    • http://purl.org/dc/terms/description
      • A germline variant, rs351855-G/A, in FGFR (c.1162G>A, p.Gly388Arg), activates the proximal STAT3 signaling pathway. This germline receptor variant, FGFR p.Gly388Arg, recruits STAT3 to inner cell membranes, resulting in increased levels of STAT3 tyrosine phosphorylation. This heritable variant-specific signaling pathway enhances both tumor-intrinsic proliferation and tumor-extrinsic immune evasion within the tumor microenvironment. The tumor-intrinsic molecular function is driven by elevated levels of tyrosine-phosphorylated STAT3 in tumor cells, promoting cell division and enhancing proliferation. Meanwhile, the tumor-extrinsic molecular function is influenced by increased levels of tyrosine-phosphorylated STAT3 in regulatory T cells and CD8 T cells. This activates the STAT3 signaling pathway predominantly in Tregs and alters the Treg/CD8 T cell ratio in lymphoid organs, thereby limiting immune surveillance within the tumor microenvironment.
    • http://purl.org/dc/terms/identifier
      • WP5428
    • http://purl.org/dc/terms/references
      • https://identifiers.org/pubmed/27314095
      • https://identifiers.org/pubmed/29438108
      • https://identifiers.org/pubmed/26675719
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/26675719
      • https://identifiers.org/pubmed/29438108
      • https://identifiers.org/pubmed/27314095
      • https://identifiers.org/pubmed/17186030
      • https://identifiers.org/pubmed/11244051
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/Complex/c6ad9
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/ComplexBinding/c6ad9
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/WP/Interaction/d8594
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/WP/Interaction/e69af
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/WP/Interaction/id103ac82b
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/WP/Interaction/id2196a4aa
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/WP/Interaction/id3fe4d585
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • http://rdf.wikipathways.org/Pathway/WP5428_r134737/WP/Interaction/id7e4af476
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/ensembl/ENSG00000136634
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/uniprot/P22301
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/uniprot/P22455
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/wikipathways/WP179
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5428_r134737
  • https://identifiers.org/wikipathways/WP5428
    • http://purl.org/pav/hasVersion
      • https://identifiers.org/wikipathways/WP5428_r134737