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http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
Tryptophan kynurenine pathway in post-COVID syndrome
http://purl.org/dc/terms/description
Following the SARS-CoV-2 pandemic, increasing evidence suggests that the overactivation of the tryptophan-kynurenine pathway (TKP) plays a significant role in the pathophysiology of post-COVID syndrome (PCS). This dysregulation is marked by reduced tryptophan (TRP) levels and elevated concentrations of specific tryptophan catabolites (TRYCATs). Notably, heightened TKP activity has been observed in patients exhibiting symptoms of post-acute sequelae of COVID-19 (PASC). In fact, elevated levels of TKP metabolites such as quinolinic acid, 3- hydroxy anthranilic acid and kynurenine, have been associated with cognitive impairments. Persistent inflammatory conditions observed in Post-Covid patients potentially upregulate the indoleamine 2,3-dioxygenase (IDO) enzymes, specifically IDO 1, as well as KMO, which catalyses the conversion from Kynurenine to 3-Hydroxykynurenine. Thus, the kynurenine pathway relates to PACS and potentially enables future biomarker and therapeutic possibilities.
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https://identifiers.org/pubmed/29031603
https://identifiers.org/pubmed/33212094
https://identifiers.org/pubmed/34072767
https://identifiers.org/pubmed/34202246
https://identifiers.org/pubmed/34290243
https://identifiers.org/pubmed/31258331
https://identifiers.org/pubmed/34315821
https://identifiers.org/pubmed/36088660
https://identifiers.org/pubmed/19826765
https://identifiers.org/pubmed/30980044
https://identifiers.org/pubmed/24200862
https://identifiers.org/pubmed/2427623
https://identifiers.org/pubmed/24567701
https://identifiers.org/pubmed/26186743
https://identifiers.org/pubmed/26589832
https://identifiers.org/pubmed/26690895
https://identifiers.org/pubmed/26767951
https://identifiers.org/pubmed/27042691
https://identifiers.org/pubmed/10852726
https://identifiers.org/pubmed/11392499
https://identifiers.org/pubmed/15866519
https://identifiers.org/pubmed/18694728
https://identifiers.org/pubmed/7514594
https://identifiers.org/pubmed/1907934
https://identifiers.org/pubmed/37318955
https://identifiers.org/pubmed/8901620
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