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• https://identifiers.org/wikipathways/WP554_r137270
  • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
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    • http://www.w3.org/2004/02/skos/core#Collection
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    • http://www.wikipathways.org/instance/WP554_r137270
  • http://purl.org/dc/elements/1.1/identifier
    • https://identifiers.org/wikipathways/WP554
  • http://purl.org/dc/elements/1.1/source
    • WikiPathways
  • http://purl.org/dc/elements/1.1/title
    • ACE inhibitor pathway
  • http://purl.org/dc/terms/description
    • The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (https://www.pharmgkb.org/pathway/PA2023) Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP554)
  • http://purl.org/dc/terms/identifier
    • WP554
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    • https://identifiers.org/pubmed/17464936
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    • https://identifiers.org/pubmed/15134803
    • https://identifiers.org/pubmed/17464936
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    • http://purl.obolibrary.org/obo/CL_0000650
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    • http://purl.obolibrary.org/obo/DOID_10763
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    • http://vocabularies.wikipathways.org/wp#Curation:Renal_Genomics
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    • http://purl.obolibrary.org/obo/DOID_10763
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    • http://purl.obolibrary.org/obo/NCBITaxon_9606
  • http://vocabularies.wikipathways.org/wp#organismName
    • Homo sapiens
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    • http://purl.obolibrary.org/obo/PW_0001228
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