SPARQL | HTML5 RDFa and Microdata document
  • https://identifiers.org/wikipathways/WP231
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP769
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q8WX94
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q9NX02
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P01375
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P04141
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P06241
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P63000
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P29350
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP619
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P10321
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P43405
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q14643
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP4172
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P01579
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P15498
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P17252
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P19174
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q04759
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP4562
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/O43561
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q13094
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/O43914
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P17706
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP3888
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q5SR36
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/b5432
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/cb53f
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/f3f50
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/f4652
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/f7ebc
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id201a7765
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id24a19f3d
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id2a40a981
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id4e73cf05
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id51729190
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id519c0edc
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id591de173
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id5c6fc4fd
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id5e36b367
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id714c9329
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id8308023b
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id958c9d45
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id9c349059
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id9da0dad6
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/id9f44df4
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/ida57f15f9
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/ida5c94156
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idad003040
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idbb259781
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idbe42dc32
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idbfb960a4
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idc2d0270
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idc6d1874d
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idc9eb38d5
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idca148a64
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/ide1392e42
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/ide2dd905f
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/ide60b0d7
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idf4198195
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • http://rdf.wikipathways.org/Pathway/WP5580_r140008/WP/Interaction/idfc864e42
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P43626
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P43627
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/P43628
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/uniprot/Q14954
    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP5580
    • http://purl.org/pav/hasVersion
      • https://identifiers.org/wikipathways/WP5580_r140008
  • https://identifiers.org/wikipathways/WP5580_r140008
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://www.w3.org/2004/02/skos/core#Collection
      • http://vocabularies.wikipathways.org/wp#Pathway
    • http://vocabularies.wikipathways.org/wp#cellTypeOntologyTag
      • http://purl.obolibrary.org/obo/CL_4052028
    • http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
      • http://purl.obolibrary.org/obo/DOID_229
    • http://vocabularies.wikipathways.org/wp#isAbout
      • http://rdf.wikipathways.org/Pathway/WP5580_r140008
    • http://vocabularies.wikipathways.org/wp#ontologyTag
      • http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
      • http://purl.obolibrary.org/obo/PW_0000003
      • http://purl.obolibrary.org/obo/DOID_229
      • http://purl.obolibrary.org/obo/CL_4052028
      • http://purl.obolibrary.org/obo/PW_0000236
      • http://purl.obolibrary.org/obo/PW_0000618
    • http://vocabularies.wikipathways.org/wp#organism
      • http://purl.obolibrary.org/obo/NCBITaxon_9606
    • http://vocabularies.wikipathways.org/wp#organismName
      • Homo sapiens
    • http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
      • http://purl.obolibrary.org/obo/PW_0000003
      • http://purl.obolibrary.org/obo/PW_0000236
      • http://purl.obolibrary.org/obo/PW_0000618
    • http://xmlns.com/foaf/0.1/img
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5580&oldid=140008
      • https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5580&oldid=140008
    • http://xmlns.com/foaf/0.1/page
      • http://www.wikipathways.org/instance/WP5580_r140008
    • http://purl.org/dc/elements/1.1/identifier
      • https://identifiers.org/wikipathways/WP5580
    • http://purl.org/dc/elements/1.1/source
      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • HLA-C allotypes interactions with KIR on dNK cells
    • http://purl.org/dc/terms/description
      • In decidual NK (dNK) cells, killer-cell immunoglobulin-like receptors (KIRs) interact with HLA-C allotypes on extravillous trophoblast (EVT) cells to modulate immune responses at the maternal–fetal interface. Inhibitory KIRs transmit signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which recruit SHP-1 and SHP-2 phosphatases to suppress activation pathways. Conversely, activating KIRs signal via the adaptor protein DAP12, whose ITAM motifs recruit SYK kinase, leading to downstream activation of LAT, SLP-76, VAV1, PLC-γ1, and NF-κB. This cascade promotes cytokine production and functional activation of dNK cells. Additionally, KIR signaling has been linked to repeated pregnancy loss (RPL), suggesting coordination between immune signaling and placental development mediated by dNK cells. The exact origin of dNK cells (phenotype CD56⁺⁺ (bright) CD16⁻) is still uncertain. Some studies suggest they may arise from CD34⁺ progenitor cells, while others propose that peripheral blood NK (pbNK) cells or local NK precursors give rise to uterine NK (uNK) cells. These uNK cells may then differentiate into either endometrial NK (eNK) cells, which are present before pregnancy, or decidual NK (dNK) cells, which appear during early pregnancy.
    • http://purl.org/dc/terms/identifier
      • WP5580
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/18322206
      • https://identifiers.org/pubmed/20189481
      • https://identifiers.org/pubmed/21070852
      • https://identifiers.org/pubmed/22238634
      • https://identifiers.org/pubmed/22786724
      • https://identifiers.org/pubmed/34016721
      • https://identifiers.org/pubmed/34267676
      • https://identifiers.org/pubmed/34790194
      • https://identifiers.org/pubmed/23066148
      • https://identifiers.org/pubmed/23071622
      • https://identifiers.org/pubmed/24091323
      • https://identifiers.org/pubmed/26327470
      • https://identifiers.org/pubmed/27956621
      • https://identifiers.org/pubmed/28546555
      • https://identifiers.org/pubmed/29449322
      • https://identifiers.org/pubmed/33335575