SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/ncbigene/109821 https://identifiers.org/ncbigene/1191 https://identifiers.org/ncbigene/1361 https://identifiers.org/ncbigene/2 https://identifiers.org/ncbigene/2152 https://identifiers.org/ncbigene/2153 https://identifiers.org/ncbigene/2155 https://identifiers.org/ncbigene/2157 https://identifiers.org/ncbigene/2158 https://identifiers.org/ncbigene/2165 https://identifiers.org/ncbigene/3998 https://identifiers.org/ncbigene/462 https://identifiers.org/ncbigene/5104 https://identifiers.org/ncbigene/5345 https://identifiers.org/ncbigene/5624 https://identifiers.org/ncbigene/7035 https://identifiers.org/ncbigene/2159 https://identifiers.org/ncbigene/2244 https://identifiers.org/ncbigene/3075 https://identifiers.org/ncbigene/3426 https://identifiers.org/ncbigene/5329 https://identifiers.org/ncbigene/5340 https://identifiers.org/ncbigene/5627 https://identifiers.org/ncbigene/7056 https://identifiers.org/ncbigene/10747 https://identifiers.org/ncbigene/1604 https://identifiers.org/ncbigene/1675 https://identifiers.org/ncbigene/5265 https://identifiers.org/ncbigene/5328 https://identifiers.org/ncbigene/5648 https://identifiers.org/ncbigene/629 https://identifiers.org/ncbigene/712 https://identifiers.org/ncbigene/713 https://identifiers.org/ncbigene/714 https://identifiers.org/ncbigene/715 https://identifiers.org/ncbigene/716 https://identifiers.org/ncbigene/717 https://identifiers.org/ncbigene/718 https://identifiers.org/ncbigene/721 https://identifiers.org/ncbigene/729 https://identifiers.org/ncbigene/730 https://identifiers.org/ncbigene/733 https://identifiers.org/ncbigene/735 https://identifiers.org/wikipathways/WP558 https://identifiers.org/cas/9001-31-4 https://identifiers.org/ncbigene/3053 https://identifiers.org/ncbigene/7450 https://identifiers.org/ncbigene/1213 https://identifiers.org/ncbigene/1378 https://identifiers.org/ncbigene/1380 https://identifiers.org/ncbigene/2161 https://identifiers.org/ncbigene/3818 https://identifiers.org/ncbigene/3827 https://identifiers.org/ncbigene/4179 https://identifiers.org/ncbigene/5054 https://identifiers.org/ncbigene/710 http://rdf.wikipathways.org/Pathway/WP558_r135894/Complex/b9e69 http://rdf.wikipathways.org/Pathway/WP558_r135894/Complex/cb502 http://rdf.wikipathways.org/Pathway/WP558_r135894/Complex/da47e http://rdf.wikipathways.org/Pathway/WP558_r135894/Complex/eb61e http://rdf.wikipathways.org/Pathway/WP558_r135894/ComplexBinding/b9e69 http://rdf.wikipathways.org/Pathway/WP558_r135894/ComplexBinding/cb502 http://rdf.wikipathways.org/Pathway/WP558_r135894/ComplexBinding/da47e http://rdf.wikipathways.org/Pathway/WP558_r135894/ComplexBinding/eb61e http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/a3a38 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/a43b9 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/a441e http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/b15ff http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/b6b65 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/ba5bf http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/bcbe2 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/beee8 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/c1f54 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/cb180 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/cea0a http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/ceec8 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/d44b0 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/e82d7 http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/ecc7e http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/eefde http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/f473a http://rdf.wikipathways.org/Pathway/WP558_r135894/WP/Interaction/fdbc5 https://identifiers.org/wikipathways/WP558_r135894
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP558_r135894
http://vocabularies.wikipathways.org/wp#ontologyTag
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://purl.obolibrary.org/obo/PW_0000502
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000502
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP558&oldid=135894
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP558&oldid=135894
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP558_r135894
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP558
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
Complement and coagulation cascades
http://purl.org/dc/terms/description
Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot.
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning.
Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens.
Source: KEGG
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP558 CPTAC Assay Portal]
http://purl.org/dc/terms/identifier https://identifiers.org/cas/58-82-2 https://identifiers.org/ncbigene/2147 https://identifiers.org/ncbigene/2149 https://identifiers.org/ncbigene/5327 https://identifiers.org/ncbigene/623 https://identifiers.org/ncbigene/719 https://identifiers.org/ncbigene/728