SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/pubmed/20067622 https://identifiers.org/ncbigene/116554 https://identifiers.org/ncbigene/116590 https://identifiers.org/ncbigene/116689 https://identifiers.org/ncbigene/117045 https://identifiers.org/ncbigene/170851 https://identifiers.org/ncbigene/170911 https://identifiers.org/ncbigene/24185 https://identifiers.org/ncbigene/24413 https://identifiers.org/ncbigene/24514 https://identifiers.org/ncbigene/24525 https://identifiers.org/ncbigene/24654 https://identifiers.org/ncbigene/24703 https://identifiers.org/ncbigene/24918 https://identifiers.org/ncbigene/25124 https://identifiers.org/ncbigene/25125 https://identifiers.org/ncbigene/25126 https://identifiers.org/ncbigene/25150 https://identifiers.org/ncbigene/25155 https://identifiers.org/ncbigene/25156 https://identifiers.org/ncbigene/252971 https://identifiers.org/ncbigene/25464 https://identifiers.org/ncbigene/25467 https://identifiers.org/ncbigene/25513 https://identifiers.org/ncbigene/25522 https://identifiers.org/ncbigene/25622 https://identifiers.org/ncbigene/25746 https://identifiers.org/ncbigene/287942 https://identifiers.org/ncbigene/289014 https://identifiers.org/ncbigene/29376 https://identifiers.org/ncbigene/294515 https://identifiers.org/ncbigene/29741 https://identifiers.org/ncbigene/298947 https://identifiers.org/ncbigene/301965 https://identifiers.org/ncbigene/309165 https://identifiers.org/ncbigene/313050 https://identifiers.org/ncbigene/313845 https://identifiers.org/ncbigene/366508 https://identifiers.org/ncbigene/500526 https://identifiers.org/ncbigene/500985 https://identifiers.org/ncbigene/50646 https://identifiers.org/ncbigene/50658 https://identifiers.org/ncbigene/54245 https://identifiers.org/ncbigene/56718 https://identifiers.org/ncbigene/58960 https://identifiers.org/ncbigene/81504 https://identifiers.org/ncbigene/81515 https://identifiers.org/ncbigene/81646 https://identifiers.org/ncbigene/81649 https://identifiers.org/ncbigene/81736 https://identifiers.org/ncbigene/83840 https://identifiers.org/ncbigene/84598 https://identifiers.org/ncbigene/85385 https://identifiers.org/ncbigene/89829 https://identifiers.org/ncbigene/50689 https://identifiers.org/ncbigene/116562 https://identifiers.org/ncbigene/140924 https://identifiers.org/ncbigene/24224 https://identifiers.org/ncbigene/24251 https://identifiers.org/ncbigene/24356 https://identifiers.org/ncbigene/25326 https://identifiers.org/ncbigene/25704 https://identifiers.org/ncbigene/288516 https://identifiers.org/ncbigene/290364 https://identifiers.org/ncbigene/298210 https://identifiers.org/ncbigene/299331 https://identifiers.org/ncbigene/304063 https://identifiers.org/ncbigene/309361 https://identifiers.org/ncbigene/311021 https://identifiers.org/ncbigene/311030 https://identifiers.org/ncbigene/498798 https://identifiers.org/ncbigene/500538 https://identifiers.org/ncbigene/83427 https://identifiers.org/ncbigene/83681 https://identifiers.org/ncbigene/84477 https://identifiers.org/ncbigene/85243 https://identifiers.org/wikipathways/WP569 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a1127 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a1b0c http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a2764 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a29eb http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a45fb http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a4784 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a58c1 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a5d1f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a6955 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a70fd http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a7e50 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a872c http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/a93a5 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/aa4eb http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/aa67f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ab0fa http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ac23f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ad95e http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ada0b http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/adee5 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/aea2b http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/afa56 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b025f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b0ad9 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b1403 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b14f4 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b19e0 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b300f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b3c44 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b5004 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b5941 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b5d2d http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b65c9 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b8cdb http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b902e http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b95b5 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/b9da3 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/bb28e http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/bbc4f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/bca36 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/bdd6d http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/be3d3 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/bf535 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c0331 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c1073 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c1be3 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c32ff http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c40bf http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c553c http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c6717 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c7a2f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c8448 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c91d3 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/c9421 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ca308 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ca5e1 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/cb897 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/cc03a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ccbd4 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ce37c http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d069c http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d171a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d1f26 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d271c http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d6117 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d7cc3 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/d88b8 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/db1d6 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/db4be http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/dd5fe http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/de292 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/de91f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/dec6a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/df354 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/df5a8 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/df716 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/df92d http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/dfad6 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e065e http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e08a5 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e0a3b http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e0c99 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e0ee6 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e1b74 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e1d72 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e2a16 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e2a56 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e40f3 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e415f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e681a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e7610 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e787a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e7bd2 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e7c09 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e8ece http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/e9fe9 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ead07 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/eaf33 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/eb19f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ebe43 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ece43 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ecfce http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f23b0 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f2e59 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f2fa6 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f3a29 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f3df6 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f4c7a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f5690 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f5dbf http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f5ed7 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f639d http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f6562 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f6658 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f6ae9 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f6cda http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f829b http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f8a8b http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f93f9 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f974a http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/f9f5f http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/fb335 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/fb8ea http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/fc4ae http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/fc6f7 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/fdf3d http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/fead8 http://rdf.wikipathways.org/Pathway/WP569_r137265/WP/Interaction/ffd3f https://identifiers.org/wikipathways/WP569_r137265
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP569_r137265
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP569
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals.
Please access this pathway at [NetSlim](http://www.netpath.org/netslim/IL_2_pathway.html) database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/20067622
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/20067622
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP569_r137265
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/PW_0000907
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#Curation:Homology_Converted
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_10116
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000907
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP569&oldid=137265
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP569&oldid=137265