SPARQL | HTML5 RDFa and Microdata document
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      • http://purl.obolibrary.org/obo/NCBITaxon_9606
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      • Homo sapiens
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      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • Type II interferon signaling
    • http://purl.org/dc/terms/description
      • Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1] Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP619).
    • http://purl.org/dc/terms/identifier
      • WP619
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      • https://identifiers.org/pubmed/18433497
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      • https://identifiers.org/pubmed/18433497