SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/chebi/CHEBI:16595 https://identifiers.org/chebi/CHEBI:18035 https://identifiers.org/chebi/CHEBI:18348 https://identifiers.org/chebi/CHEBI:29108 https://identifiers.org/hmdb/HMDB0004249 https://identifiers.org/ncbigene/1978 https://identifiers.org/wikipathways/WP254 https://identifiers.org/wikipathways/WP382 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/a7394 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/bd909 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/bdec0 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/cb274 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/d3530 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/d3dd0 http://rdf.wikipathways.org/Pathway/WP673_r137058/Complex/dd4d4 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/a7394 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/bd909 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/bdec0 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/cb274 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/d3530 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/d3dd0 http://rdf.wikipathways.org/Pathway/WP673_r137058/ComplexBinding/dd4d4 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/a1e4b http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/a3389 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/adb98 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/b9abd http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/c059c http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/c4820 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/c5c47 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/cf71a http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/d0cfc http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/d1259 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/d1a2a http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/d719d http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/d919c http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/deddc http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/e117d http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/e3a47 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/ec8f5 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/eea3b http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/f03f4 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/fb091 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/id80273925 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/id82c0ddb0 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/idad13e4c1 http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/idebce069e http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/idf6da08cb http://rdf.wikipathways.org/Pathway/WP673_r137058/WP/Interaction/idfc5e9547 https://identifiers.org/wikipathways/WP673_r137058
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP673_r137058
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP673
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.
The ErbB protein family consists of 4 members
* ErbB-1, also named epidermal growth factor receptor (EGFR)
* ErbB-2, also named HER2 in humans and neu in rodents
* ErbB-3, also named HER3 and
* ErbB-4, also named HER4
The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP673).
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/10490623
https://identifiers.org/pubmed/10880430
https://identifiers.org/pubmed/12851486
https://identifiers.org/pubmed/14967450
https://identifiers.org/pubmed/14744244
https://identifiers.org/pubmed/11252954
https://identifiers.org/pubmed/16729043
https://identifiers.org/pubmed/15863494
https://identifiers.org/pubmed/15864276
https://identifiers.org/pubmed/25514926
https://identifiers.org/pubmed/16377102
https://identifiers.org/pubmed/9642287
https://identifiers.org/pubmed/17000658
https://identifiers.org/pubmed/16829981
https://identifiers.org/pubmed/16729045
https://identifiers.org/pubmed/9872057
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/10490623
https://identifiers.org/pubmed/10880430
https://identifiers.org/pubmed/12851486
https://identifiers.org/pubmed/14967450
https://identifiers.org/pubmed/14744244
https://identifiers.org/pubmed/16729043
https://identifiers.org/pubmed/11252954
https://identifiers.org/pubmed/19419954
https://identifiers.org/pubmed/15863494
https://identifiers.org/pubmed/15864276
https://identifiers.org/pubmed/25514926
https://identifiers.org/pubmed/9642287
https://identifiers.org/pubmed/16377102
https://identifiers.org/pubmed/17000658
https://identifiers.org/pubmed/16729045
https://identifiers.org/pubmed/9872057
https://identifiers.org/pubmed/20573930
https://identifiers.org/pubmed/16829981
http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
http://purl.obolibrary.org/obo/DOID_10652
http://purl.obolibrary.org/obo/DOID_162
http://purl.obolibrary.org/obo/DOID_2377
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP673_r137058
http://vocabularies.wikipathways.org/wp#ontologyTag
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://purl.obolibrary.org/obo/DOID_162
http://purl.obolibrary.org/obo/DOID_10652
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://purl.obolibrary.org/obo/PW_0000170
http://purl.obolibrary.org/obo/PW_0001059
http://purl.obolibrary.org/obo/DOID_2377
http://vocabularies.wikipathways.org/wp#Curation:ExRNA
http://vocabularies.wikipathways.org/wp#Curation:PancCanNet
http://vocabularies.wikipathways.org/wp#Curation:CPTAC
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000170
http://purl.obolibrary.org/obo/PW_0001059
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP673&oldid=137058
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP673&oldid=137058
https://identifiers.org/ncbigene/2475 https://identifiers.org/wikipathways/WP179 https://identifiers.org/ncbigene/1026 https://identifiers.org/ensembl/ENSG00000082701 https://identifiers.org/ensembl/ENSG00000140992 https://identifiers.org/ncbigene/10000 https://identifiers.org/ncbigene/10018 https://identifiers.org/ncbigene/1027 https://identifiers.org/ncbigene/10298 https://identifiers.org/ncbigene/106821730 https://identifiers.org/ncbigene/1398 https://identifiers.org/ncbigene/1839 https://identifiers.org/ncbigene/1956 https://identifiers.org/ncbigene/2002 https://identifiers.org/ncbigene/207 https://identifiers.org/ncbigene/208 https://identifiers.org/ncbigene/2308 https://identifiers.org/ncbigene/25 https://identifiers.org/ncbigene/25759 https://identifiers.org/ncbigene/3265 https://identifiers.org/ncbigene/3725 https://identifiers.org/ncbigene/4193 https://identifiers.org/ncbigene/4609 https://identifiers.org/ncbigene/4893 https://identifiers.org/ncbigene/5058 https://identifiers.org/ncbigene/5062 https://identifiers.org/ncbigene/5063 https://identifiers.org/ncbigene/5290 https://identifiers.org/ncbigene/5291 https://identifiers.org/ncbigene/5293 https://identifiers.org/ncbigene/5295 https://identifiers.org/ncbigene/5296 https://identifiers.org/ncbigene/53358 https://identifiers.org/ncbigene/5336 https://identifiers.org/ncbigene/5578 https://identifiers.org/ncbigene/5579 https://identifiers.org/ncbigene/5594 https://identifiers.org/ncbigene/5595 https://identifiers.org/ncbigene/5599 https://identifiers.org/ncbigene/5601 https://identifiers.org/ncbigene/5602 https://identifiers.org/ncbigene/5604 https://identifiers.org/ncbigene/5605 https://identifiers.org/ncbigene/5609 https://identifiers.org/ncbigene/56924 https://identifiers.org/ncbigene/57144 https://identifiers.org/ncbigene/572 https://identifiers.org/ncbigene/5894 https://identifiers.org/ncbigene/595 https://identifiers.org/ncbigene/6198 https://identifiers.org/ncbigene/6199 https://identifiers.org/ncbigene/6416 https://identifiers.org/ncbigene/6464 https://identifiers.org/ncbigene/6654 https://identifiers.org/ncbigene/6655 https://identifiers.org/ncbigene/6714 https://identifiers.org/ncbigene/7039 https://identifiers.org/ncbigene/7157 https://identifiers.org/ncbigene/815 https://identifiers.org/ncbigene/816 https://identifiers.org/ncbigene/817 https://identifiers.org/ncbigene/8503 https://identifiers.org/ncbigene/867 https://identifiers.org/ncbigene/868 https://identifiers.org/pubmed/16729043 https://identifiers.org/pubmed/25514926 https://identifiers.org/ensembl/ENSG00000284190 https://identifiers.org/ncbigene/10718 https://identifiers.org/ncbigene/1399 https://identifiers.org/ncbigene/145957 https://identifiers.org/ncbigene/2064 https://identifiers.org/ncbigene/2065 https://identifiers.org/ncbigene/2069 https://identifiers.org/ncbigene/374 https://identifiers.org/ncbigene/685 https://identifiers.org/ncbigene/818 https://identifiers.org/ncbigene/8440 https://identifiers.org/ncbigene/9542 https://identifiers.org/pubmed/10490623 https://identifiers.org/pubmed/10880430 https://identifiers.org/pubmed/11252954 https://identifiers.org/pubmed/12851486 https://identifiers.org/pubmed/14744244 https://identifiers.org/pubmed/14967450 https://identifiers.org/pubmed/15863494 https://identifiers.org/pubmed/15864276 https://identifiers.org/pubmed/16377102 https://identifiers.org/pubmed/16729045 https://identifiers.org/pubmed/16829981 https://identifiers.org/pubmed/17000658 https://identifiers.org/pubmed/9642287 https://identifiers.org/pubmed/9872057 https://identifiers.org/wikipathways/WP673 https://identifiers.org/ensembl/ENSG00000078061 https://identifiers.org/ncbigene/1950 https://identifiers.org/ncbigene/2066 https://identifiers.org/ncbigene/2549 https://identifiers.org/ncbigene/27 https://identifiers.org/ncbigene/2885 https://identifiers.org/ncbigene/3084 https://identifiers.org/ncbigene/3845 https://identifiers.org/ncbigene/399694 https://identifiers.org/ncbigene/4690 https://identifiers.org/ncbigene/5335 https://identifiers.org/ncbigene/5582 https://identifiers.org/ncbigene/5747 https://identifiers.org/ncbigene/673 https://identifiers.org/ncbigene/6776 https://identifiers.org/ncbigene/6777