SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/pubmed/15748653 https://identifiers.org/pubmed/16258029 https://identifiers.org/pubmed/17164131 https://identifiers.org/pubmed/18216721 https://identifiers.org/pubmed/3977905 http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/c8864 http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/cba10 http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/cccad http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/db474 http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/ec492 http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/edaa6 http://rdf.wikipathways.org/Pathway/WP678_r134379/WP/Interaction/fc673 https://identifiers.org/wikipathways/WP678_r134379
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http://purl.obolibrary.org/obo/PW_0000460
http://purl.obolibrary.org/obo/PW_0000147
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http://purl.obolibrary.org/obo/NCBITaxon_9606
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Arachidonate epoxygenase / epoxide hydrolase
http://purl.org/dc/terms/description
The cytochrome P450-dependent formation of polyunsaturated fatty acid epoxides is an important biochemical pathway creating mediators of inflammation and blood pressure regulation. Once formed these compounds can be incorperated into phospholipid membrance, and released by the action of phospholipase A2. The epoxides of arachidonic acid, i.e. the epoxyeicosatrieneoic acid or EETs, are putative endothelial derived hyperpolarization factors which increase the open state probability of Ca++ sensitive K+ channels, leading to vasodilation in arteriolar beds. The 11(12)-EET in particular appears to have potent functions in vasodilation, and are inhibitors of NFKb dependent inflammatory signalling, and PAI-1 activity. The 5(6)-EET appears unique, in that its metabolic transformation through cyclooxygenase activities produces potent vasoconstrictors. With the exception of the 5(6)-EET, these epoxy fatty acids are good substrates for the soluble epoxide hydrolase. Hydrolytic tranformation to vicinal diols eliminates vasoactive actions, however these vicinal diols have been reported to have other biological activites, including PPAR-alpha activation. Recent development of inhibitors of the soluble epoxide hydrolase are proving to have potent anti-inflammatory, anti-hypertensive, and anti-nociceptive properties. Reports of enzyme catalyzed glutathione-conjugates of the epoxy fatty acids have been reported, but the activity and relavance of these potential metabolic products are unknown to date.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/10759591
https://identifiers.org/pubmed/3619897
https://identifiers.org/pubmed/4051502
https://identifiers.org/pubmed/18216721
https://identifiers.org/pubmed/2834948
https://identifiers.org/pubmed/17164131
https://identifiers.org/pubmed/16258029
https://identifiers.org/pubmed/15748653
https://identifiers.org/pubmed/18383502
https://identifiers.org/pubmed/17975109
https://identifiers.org/pubmed/15180494
https://identifiers.org/pubmed/14626496
https://identifiers.org/pubmed/14636671
https://identifiers.org/pubmed/3977905
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/17164131
https://identifiers.org/pubmed/17494091
https://identifiers.org/pubmed/18216721
https://identifiers.org/pubmed/2834948
https://identifiers.org/pubmed/15748653
https://identifiers.org/pubmed/16179585
https://identifiers.org/pubmed/16258029
https://identifiers.org/pubmed/16399376
https://identifiers.org/pubmed/6548162
https://identifiers.org/pubmed/17975109
https://identifiers.org/pubmed/18383502
https://identifiers.org/pubmed/14626496
https://identifiers.org/pubmed/14636671
https://identifiers.org/pubmed/15180494
https://identifiers.org/pubmed/3619897
https://identifiers.org/pubmed/4051502
https://identifiers.org/pubmed/3977905
https://identifiers.org/pubmed/10759591
https://identifiers.org/ensembl/ENSG00000134716 https://identifiers.org/hmdb/HMDB0001043 https://identifiers.org/hmdb/HMDB0002190 https://identifiers.org/hmdb/HMDB0002232 https://identifiers.org/hmdb/HMDB0002265 https://identifiers.org/hmdb/HMDB0002311 https://identifiers.org/hmdb/HMDB0002314 https://identifiers.org/hmdb/HMDB0002343 https://identifiers.org/hmdb/HMDB0004264 https://identifiers.org/hmdb/HMDB0010409 https://identifiers.org/ncbigene/1351 https://identifiers.org/ncbigene/1558 https://identifiers.org/ncbigene/1559 https://identifiers.org/ncbigene/2053 https://identifiers.org/ncbigene/2950 https://identifiers.org/ncbigene/9377 https://identifiers.org/pubchem.compound/53481368 https://identifiers.org/pubmed/10759591 https://identifiers.org/pubmed/14626496 https://identifiers.org/pubmed/14636671 https://identifiers.org/pubmed/15180494 https://identifiers.org/pubmed/17975109 https://identifiers.org/pubmed/18383502 https://identifiers.org/pubmed/2834948 https://identifiers.org/pubmed/3619897 https://identifiers.org/pubmed/4051502 https://identifiers.org/wikipathways/WP678