SPARQL | HTML5 RDFa and Microdata document
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Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.
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https://identifiers.org/pubmed/15688067
https://identifiers.org/pubmed/15179030
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https://identifiers.org/pubmed/14756624
https://identifiers.org/pubmed/15034601
https://identifiers.org/pubmed/11082269
https://identifiers.org/pubmed/15053919
https://identifiers.org/pubmed/15108811
https://identifiers.org/pubmed/12235283
https://identifiers.org/pubmed/12640026
https://identifiers.org/pubmed/14519391
https://identifiers.org/pubmed/11882383
https://identifiers.org/pubmed/11229600
https://identifiers.org/pubmed/11573199
https://identifiers.org/pubmed/11146675
https://identifiers.org/pubmed/14744429
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https://identifiers.org/pubmed/14744429
https://identifiers.org/pubmed/10698680
https://identifiers.org/pubmed/11082269
https://identifiers.org/pubmed/11146675
https://identifiers.org/pubmed/11229600
https://identifiers.org/pubmed/11573199
https://identifiers.org/pubmed/11882383
https://identifiers.org/pubmed/12235283
https://identifiers.org/pubmed/12640026
https://identifiers.org/pubmed/14519391
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