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    • http://purl.obolibrary.org/obo/NCBITaxon_9598
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    • Pan troglodytes
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    • http://purl.obolibrary.org/obo/PW_0000094
    • http://purl.obolibrary.org/obo/PW_0000095
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    • WikiPathways
  • http://purl.org/dc/elements/1.1/title
    • G1 to S cell cycle control
  • http://purl.org/dc/terms/description
    • In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
  • http://purl.org/dc/terms/identifier
    • WP959
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    • https://identifiers.org/pubmed/12164919
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    • https://identifiers.org/pubmed/12164919