SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/ensembl/ENSBTAG00000000816 https://identifiers.org/ensembl/ENSBTAG00000011136 https://identifiers.org/ensembl/ENSBTAG00000011698 https://identifiers.org/ensembl/ENSBTAG00000012046 https://identifiers.org/ensembl/ENSBTAG00000013400 https://identifiers.org/ensembl/ENSBTAG00000013907 https://identifiers.org/ensembl/ENSBTAG00000017745 https://identifiers.org/ensembl/ENSBTAG00000018137 https://identifiers.org/ensembl/ENSBTAG00000018474 https://identifiers.org/wikipathways/WP976 https://identifiers.org/ensembl/ENSBTAG00000008441 https://identifiers.org/ensembl/ENSBTAG00000012103 https://identifiers.org/ensembl/ENSBTAG00000012698 https://identifiers.org/ensembl/ENSBTAG00000026403 https://identifiers.org/ensembl/ENSBTAG00000031231 https://identifiers.org/ensembl/ENSBTAG00000005043 https://identifiers.org/ensembl/ENSBTAG00000006526 https://identifiers.org/ensembl/ENSBTAG00000012511 https://identifiers.org/ensembl/ENSBTAG00000016851 https://identifiers.org/ensembl/ENSBTAG00000002048 https://identifiers.org/ensembl/ENSBTAG00000002625 https://identifiers.org/ensembl/ENSBTAG00000002813 https://identifiers.org/ensembl/ENSBTAG00000003147 https://identifiers.org/ensembl/ENSBTAG00000004736 https://identifiers.org/ensembl/ENSBTAG00000007867 https://identifiers.org/ensembl/ENSBTAG00000007932 https://identifiers.org/ensembl/ENSBTAG00000008719 https://identifiers.org/ensembl/ENSBTAG00000009233 https://identifiers.org/ensembl/ENSBTAG00000010312 https://identifiers.org/ensembl/ENSBTAG00000010989 https://identifiers.org/ensembl/ENSBTAG00000011643 https://identifiers.org/ensembl/ENSBTAG00000012047 https://identifiers.org/ensembl/ENSBTAG00000012393 https://identifiers.org/ensembl/ENSBTAG00000014921 https://identifiers.org/ensembl/ENSBTAG00000015007 https://identifiers.org/ensembl/ENSBTAG00000016156 https://identifiers.org/ensembl/ENSBTAG00000017636 https://identifiers.org/ensembl/ENSBTAG00000019838 https://identifiers.org/ensembl/ENSBTAG00000021523 https://identifiers.org/ensembl/ENSBTAG00000024450 https://identifiers.org/ensembl/ENSBTAG00000033983 https://identifiers.org/ensembl/ENSBTAG00000039160 https://identifiers.org/ensembl/ENSBTAG00000048057 https://identifiers.org/pubmed/20067622 https://identifiers.org/ensembl/ENSBTAG00000014825 http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/a02cc http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/a129c http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/a35fb http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/aec50 http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/b5e69 http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/b9bfa http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/f0185 http://rdf.wikipathways.org/Pathway/WP976_r136887/Complex/ff443 http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/a02cc http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/a129c http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/a35fb http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/aec50 http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/b5e69 http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/b9bfa http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/f0185 http://rdf.wikipathways.org/Pathway/WP976_r136887/ComplexBinding/ff443 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/a2174 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/a5a98 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/a78bf http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/acd90 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/ae1f7 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/b19a1 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/b90ca http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/bb10d http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/c2a00 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/c446c http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/c4dbb http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/c5f4b http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/c6cdb http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/c7e27 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/cf0f7 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/d26cf http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/d89ae http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/d9db2 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/da3c7 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/da787 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/dafb3 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/dd8ed http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/e02c1 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/e0742 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/e2949 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/e37a7 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/e9668 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/e9fb4 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/eb479 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/ec818 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/ed7d6 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/f5f58 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/f678b http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/f7b60 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/f947f http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/fd9cf http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/fdb51 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/id33e0b7ef http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/id3476e0e7 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/id48fe0c81 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/idbd6868f7 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/ideb7f66d0 http://rdf.wikipathways.org/Pathway/WP976_r136887/WP/Interaction/idf1eb44c8 https://identifiers.org/wikipathways/WP976_r136887
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP976_r136887
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/PW_0000512
http://vocabularies.wikipathways.org/wp#Curation:Homology_Converted
http://purl.obolibrary.org/obo/PW_0000516
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9913
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000516
http://purl.obolibrary.org/obo/PW_0000512
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP976&oldid=136887
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP976&oldid=136887
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP976_r136887
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP976
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
IL-6 is a pleiotropic cytokine with important role in immune regulation, hematopoiesis, inflammation and oncogenesis. IL-6-type cytokines exert their action via the signal transducer gp130 that associates with IL6R in a cooperative manner to form a hexameric signal transducing complex, capable of activating the down stream mediators of this signaling pathway. This mechanism of signal transduction is shared by other members of the IL-6 type cytokines like IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1 that use gp130 as a common subunit of the signal transducing complex. IL-6 stimulation leads to the activation of JAK/STAT pathway. Both STAT1 and STAT3 are phosphorylated and are able to form homo- and heterodimers after activation leading to their nuclear localization and subsequent regulation of transcription of respective target genes. SHP-2 is one of the ubiquitous tyrosine phosphatases and IL-6 stimulation leads to the SHP2-dependent activation of MAPKs, it also links the Grb2-SOS complex and Gab1 to gp130. Phosphorylated Gab1 acts as an adapter and is involved in the indirect association of SHP-2 and PI-3 kinase. Downstream activation of Vav1, Rac-1 and MAP2K4 is necessary for the IL-6-mediated STAT3 phosphorylation and transactivation to accomplish its effects. STAT3 is also phosphorylated by PKCD and it causes inhibition of STAT3 DNA binding and transcriptional activity. PTPN11 and SOCS3 exert inhibitory function and thus lead to down regulation of the signaling cascade.
Please access this pathway at [NetSlim](http://www.netpath.org/netslim/IL_6_pathway.html) database.
If you use this pathway, please cite following paper:
Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. <i>Genome Biology</i>. 11:R3.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/20067622
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/20067622