SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/ensembl/ENSBTAG00000000218 https://identifiers.org/ensembl/ENSBTAG00000000308 https://identifiers.org/ensembl/ENSBTAG00000000369 https://identifiers.org/ensembl/ENSBTAG00000000411 https://identifiers.org/ensembl/ENSBTAG00000001061 https://identifiers.org/ensembl/ENSBTAG00000001403 https://identifiers.org/ensembl/ENSBTAG00000001774 https://identifiers.org/ensembl/ENSBTAG00000001835 https://identifiers.org/ensembl/ENSBTAG00000001887 https://identifiers.org/ensembl/ENSBTAG00000002658 https://identifiers.org/ensembl/ENSBTAG00000003063 https://identifiers.org/ensembl/ENSBTAG00000003185 https://identifiers.org/ensembl/ENSBTAG00000003237 https://identifiers.org/ensembl/ENSBTAG00000003341 https://identifiers.org/ensembl/ENSBTAG00000003525 https://identifiers.org/ensembl/ENSBTAG00000003727 https://identifiers.org/ensembl/ENSBTAG00000003825 https://identifiers.org/ensembl/ENSBTAG00000003971 https://identifiers.org/ensembl/ENSBTAG00000004194 https://identifiers.org/ensembl/ENSBTAG00000004216 https://identifiers.org/ensembl/ENSBTAG00000004322 https://identifiers.org/ensembl/ENSBTAG00000004879 https://identifiers.org/ensembl/ENSBTAG00000004953 https://identifiers.org/ensembl/ENSBTAG00000005136 https://identifiers.org/ensembl/ENSBTAG00000005542 https://identifiers.org/ensembl/ENSBTAG00000005550 https://identifiers.org/ensembl/ENSBTAG00000005958 https://identifiers.org/ensembl/ENSBTAG00000006065 https://identifiers.org/ensembl/ENSBTAG00000006609 https://identifiers.org/ensembl/ENSBTAG00000006661 https://identifiers.org/ensembl/ENSBTAG00000006697 https://identifiers.org/ensembl/ENSBTAG00000007489 https://identifiers.org/ensembl/ENSBTAG00000007783 https://identifiers.org/ensembl/ENSBTAG00000008151 https://identifiers.org/ensembl/ENSBTAG00000008182 https://identifiers.org/ensembl/ENSBTAG00000009494 https://identifiers.org/ensembl/ENSBTAG00000009498 https://identifiers.org/ensembl/ENSBTAG00000009565 https://identifiers.org/ensembl/ENSBTAG00000009578 https://identifiers.org/ensembl/ENSBTAG00000009600 https://identifiers.org/ensembl/ENSBTAG00000009990 https://identifiers.org/ensembl/ENSBTAG00000010584 https://identifiers.org/ensembl/ENSBTAG00000010649 https://identifiers.org/ensembl/ENSBTAG00000010662 https://identifiers.org/ensembl/ENSBTAG00000010906 https://identifiers.org/ensembl/ENSBTAG00000011307 https://identifiers.org/ensembl/ENSBTAG00000011628 https://identifiers.org/ensembl/ENSBTAG00000011916 https://identifiers.org/ensembl/ENSBTAG00000012002 https://identifiers.org/ensembl/ENSBTAG00000013009 https://identifiers.org/ensembl/ENSBTAG00000013057 https://identifiers.org/ensembl/ENSBTAG00000013060 https://identifiers.org/ensembl/ENSBTAG00000013392 https://identifiers.org/ensembl/ENSBTAG00000013790 https://identifiers.org/ensembl/ENSBTAG00000013793 https://identifiers.org/ensembl/ENSBTAG00000014103 https://identifiers.org/ensembl/ENSBTAG00000014119 https://identifiers.org/ensembl/ENSBTAG00000014710 https://identifiers.org/ensembl/ENSBTAG00000015205 https://identifiers.org/ensembl/ENSBTAG00000015311 https://identifiers.org/ensembl/ENSBTAG00000016851 https://identifiers.org/ensembl/ENSBTAG00000017086 https://identifiers.org/ensembl/ENSBTAG00000017490 https://identifiers.org/ensembl/ENSBTAG00000017639 https://identifiers.org/ensembl/ENSBTAG00000017681 https://identifiers.org/ensembl/ENSBTAG00000017869 https://identifiers.org/ensembl/ENSBTAG00000017976 https://identifiers.org/ensembl/ENSBTAG00000018004 https://identifiers.org/ensembl/ENSBTAG00000018115 https://identifiers.org/ensembl/ENSBTAG00000018131 https://identifiers.org/ensembl/ENSBTAG00000018912 https://identifiers.org/ensembl/ENSBTAG00000018966 https://identifiers.org/ensembl/ENSBTAG00000019167 https://identifiers.org/ensembl/ENSBTAG00000019180 https://identifiers.org/ensembl/ENSBTAG00000019488 https://identifiers.org/ensembl/ENSBTAG00000020079 https://identifiers.org/ensembl/ENSBTAG00000020106 https://identifiers.org/ensembl/ENSBTAG00000020257 https://identifiers.org/ensembl/ENSBTAG00000020316 https://identifiers.org/ensembl/ENSBTAG00000021250 https://identifiers.org/ensembl/ENSBTAG00000021364 https://identifiers.org/ensembl/ENSBTAG00000021424 https://identifiers.org/ensembl/ENSBTAG00000021446 https://identifiers.org/ensembl/ENSBTAG00000021634 https://identifiers.org/ensembl/ENSBTAG00000021741 https://identifiers.org/ensembl/ENSBTAG00000022069 https://identifiers.org/ensembl/ENSBTAG00000022227 https://identifiers.org/ensembl/ENSBTAG00000024470 https://identifiers.org/ensembl/ENSBTAG00000024633 https://identifiers.org/ensembl/ENSBTAG00000026505 https://identifiers.org/ensembl/ENSBTAG00000031261 https://identifiers.org/ensembl/ENSBTAG00000031575 https://identifiers.org/ensembl/ENSBTAG00000032021 https://identifiers.org/ensembl/ENSBTAG00000044091 https://identifiers.org/ensembl/ENSBTAG00000045584 https://identifiers.org/ensembl/ENSBTAG00000045980 https://identifiers.org/ensembl/ENSBTAG00000046385 https://identifiers.org/ensembl/ENSBTAG00000046922 https://identifiers.org/ensembl/ENSBTAG00000046996 https://identifiers.org/wikipathways/WP978 https://identifiers.org/ensembl/ENSBTAG00000001014 https://identifiers.org/ensembl/ENSBTAG00000001700 https://identifiers.org/ensembl/ENSBTAG00000002048 https://identifiers.org/ensembl/ENSBTAG00000002813 https://identifiers.org/ensembl/ENSBTAG00000003021 https://identifiers.org/ensembl/ENSBTAG00000003147 https://identifiers.org/ensembl/ENSBTAG00000004037 https://identifiers.org/ensembl/ENSBTAG00000004511 https://identifiers.org/ensembl/ENSBTAG00000004709 https://identifiers.org/ensembl/ENSBTAG00000004736 https://identifiers.org/ensembl/ENSBTAG00000005474 https://identifiers.org/ensembl/ENSBTAG00000005665 https://identifiers.org/ensembl/ENSBTAG00000006817 https://identifiers.org/ensembl/ENSBTAG00000007867 https://identifiers.org/ensembl/ENSBTAG00000007876 https://identifiers.org/ensembl/ENSBTAG00000008403 https://identifiers.org/ensembl/ENSBTAG00000008719 https://identifiers.org/ensembl/ENSBTAG00000008938 https://identifiers.org/ensembl/ENSBTAG00000009233 https://identifiers.org/ensembl/ENSBTAG00000009496 https://identifiers.org/ensembl/ENSBTAG00000009907 https://identifiers.org/ensembl/ENSBTAG00000010125 https://identifiers.org/ensembl/ENSBTAG00000010191 https://identifiers.org/ensembl/ENSBTAG00000010312 https://identifiers.org/ensembl/ENSBTAG00000010989 https://identifiers.org/ensembl/ENSBTAG00000011643 https://identifiers.org/ensembl/ENSBTAG00000012047 https://identifiers.org/ensembl/ENSBTAG00000014447 https://identifiers.org/ensembl/ENSBTAG00000015325 https://identifiers.org/ensembl/ENSBTAG00000015817 https://identifiers.org/ensembl/ENSBTAG00000017584 https://identifiers.org/ensembl/ENSBTAG00000017636 https://identifiers.org/ensembl/ENSBTAG00000017680 https://identifiers.org/ensembl/ENSBTAG00000018427 https://identifiers.org/ensembl/ENSBTAG00000019838 https://identifiers.org/ensembl/ENSBTAG00000020087 https://identifiers.org/ensembl/ENSBTAG00000020173 https://identifiers.org/ensembl/ENSBTAG00000020701 https://identifiers.org/ensembl/ENSBTAG00000020783 https://identifiers.org/ensembl/ENSBTAG00000020921 https://identifiers.org/ensembl/ENSBTAG00000021145 https://identifiers.org/ensembl/ENSBTAG00000021455 https://identifiers.org/ensembl/ENSBTAG00000021523 https://identifiers.org/ensembl/ENSBTAG00000021761 https://identifiers.org/ensembl/ENSBTAG00000021798 https://identifiers.org/ensembl/ENSBTAG00000024450 https://identifiers.org/ensembl/ENSBTAG00000027654 https://identifiers.org/ensembl/ENSBTAG00000033983 https://identifiers.org/ensembl/ENSBTAG00000034436 https://identifiers.org/ensembl/ENSBTAG00000039160 https://identifiers.org/ensembl/ENSBTAG00000043556 https://identifiers.org/ensembl/ENSBTAG00000044105 https://identifiers.org/ensembl/ENSBTAG00000045548 https://identifiers.org/ensembl/ENSBTAG00000045748 https://identifiers.org/ensembl/ENSBTAG00000046545 https://identifiers.org/ensembl/ENSBTAG00000046644 https://identifiers.org/pubmed/20067622 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/a3937 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/a466b http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ad403 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/adadc http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/adee4 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b1334 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b1d18 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b297e http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b2ccc http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b7d68 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b83df http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b98bb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/b9e13 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ba478 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/bab7a http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/bc0a3 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/bcc53 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/bd059 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/c05bc http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/c161a http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/c54e7 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/c72cd http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/c9b17 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/c9c39 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/cb500 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/cb7ff http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ced46 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/cf17e http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/d01dc http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/d1c67 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/d4413 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/d6364 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/d85a2 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/da723 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/db525 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/dc59b http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/dcd68 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/defc1 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/e2ddb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/e4d36 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/e5e09 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/e920f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/e9a15 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ea452 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ec5bd http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/edcba http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f0fa1 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f150e http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f19d6 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f205d http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f3076 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f43e6 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f703f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f7c61 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f88c2 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/f9953 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/faf83 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/fb091 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/fb9db http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/fca54 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/fd330 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/feedb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ff0a2 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ff1fd http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id105e7b14 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id126717cb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id1398eeb5 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id17276a09 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id1e26338f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id23d3733b http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id24166ba8 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id25d96de8 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id27c90ad6 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id27d0279c http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id2b252a60 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id2e4b9330 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id3094e08d http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id327a4599 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id33a7a679 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id38d7d743 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id3b09e289 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id3c80dfca http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id41237d55 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id448a181c http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id47b387c0 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id48294ead http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id48ae2e4c http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id4ccc87a8 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id4cd0f431 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id5b7ca513 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id5cd848cf http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id5fc3e288 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id6bd4c90e http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id6ce0419f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id749369fb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id76733cbd http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id76c3aab7 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id7af097b1 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id7f15b561 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id7f781aa http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id81cdfb99 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id83144a70 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id8423799e http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id85e319db http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id877b8a47 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id896ca472 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id92b71308 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id93d03307 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id95489c86 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id9a126e98 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id9a14a63b http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/id9f07878f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ida830ca24 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ida926d05b http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idab68bf82 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idabb5eeeb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idac680492 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idb08dfba3 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idb1c149ca http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idb2ffb4b1 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idc49d5018 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idc5d47f6f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idc5d7a343 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idca58abac http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idcc9431c7 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idcdbd3265 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idcee33612 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idd3f2f8eb http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/iddc03b164 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ide3829360 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ide43611ce http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ide77e8657 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ide7ff596 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ide94fdc05 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/ide9636e3f http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idee8cff60 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idf0c548e1 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idf1622338 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idf222df2a http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idf2fcffa http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idf80fc4a6 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idfb8c9b1d http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idfcadecd3 http://rdf.wikipathways.org/Pathway/WP978_r119000/WP/Interaction/idfd4c1efb https://identifiers.org/wikipathways/WP978_r119000
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP978_r119000
http://vocabularies.wikipathways.org/wp#ontologyTag
http://vocabularies.wikipathways.org/wp#Curation:Homology_Converted
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://purl.obolibrary.org/obo/PW_0000170
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9913
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000170
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP978&oldid=119000
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP978&oldid=119000
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP978_r119000
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP978
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
EGF/EGFR signaling pathway
http://purl.org/dc/terms/description
Epidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases
which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Several ligands such as epidermal growth factor, transforming growth factor-alpha, epigen,
amphiregulin, betacellulin, heparin-binding EGF and epiregulin are known to specifically bind to EGFR. Epidermal growth factor (EGF) is one of the high affinity
ligands of EGFR. EGF/EGFR system induces growth, differentiation, migration, adhesion and cell survival through various inter-acting signaling pathways. The binding of
EGF to the extracellular domain of EGFR induces the dimerization, activation of intrinsic kinase activity and subsequent autophosphorylation of EGFR at multiple residues
in the cytoplasmic region such as Tyr 1092, Tyr 1172, Tyr 1197, Tyr 1110, Tyr 1016). Activated EGFR recruits various cytoplasmic proteins which transduce and regulate the
EGFR function. The proteins recruited to active EGFR include many Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain containing proteins which binds to the
tyrosine phosphorylated residues in EGFR, enzymes which act on EGFR and also various EGFR substrates. One of the adapter proteins, GRB2, binds to the phosphotyrosine
residue at 1068 and recruits SOS to the membrane. SOS activates GDP/GTP exchange which recruits RAF to the membrane. RAF phosphorylates MEKs, which then activates the
extracellular signal regulated kinase (ERK). ERK activates a number of transcriptional regulators to induce cell growth and proliferation. GRB2 or other adaptor proteins
such as GABs recruits PI3Ks, another major mediator of EGFR signaling. PI3Ks convert Phosphatidylinositol-4,5-bisphosphate (PIP2) to Phosphatidylinositol-3,4,5-trisphosphate (PIP3).
PIP3 binds to PH domain of AKT and recruits it to plasma membrane. PDK1 phosphorylates AKT which in turn regulate the activity of various proteins that mediate cell
survival. EGFR also activate phospholipase C which hydrolyses PIP2 to generate Inositol trisphosphate (IP3) and 1,2-Diacylglycerol (DAG). IP3 induces the release of Ca2+
from endoplasmic reticulum to activate calcium regulated pathways. DAG activates protein kinase C pathway. One of the signaling modules regulated by PKC in EGFR pathway is
the NFKB module. The protein SRC is a key player in the activation of various pathways such as RAS, PLC and also the STAT proteins in various cells. Other signaling modules
activated by EGFR include the FAK, JNK, p38MAPK and ERK5 modules. EGFR induces the JNK pathway through the activation of G proteins such as RAC and CDC42 which recruits JNK
kinases as well as regulate the actin polymerization. EGFR also translocates from the plasma membrane to other cellular compartments including nucleus where it directly
regulate the expression of several genes in cooperation with other transcriptional regulators such as STATs, PCNA and E2F family of proteins. Being a growth, differentiation
and cell survival factor; mutations and overexpression of EGFR and also the defective regulation of its signal transduction pathways has been established to be associated
with oncogenesis. Thus, EGFR and its signaling components are promising targets for effective therapy for various cancers. There are several proteins which have been reported
to regulate the EGFR signaling such as CBL, CSK, PKC and PTEN which promotes endocytosis or reduction in the EGFR activity or its signaling mediators. The major endocytic pathway
of EGFR is established to be the clathrin coated pits which delivers them to endosomes. The endosomal pathway recycles the membraneous form of EGFR or form multivesicular bodies (MVB)
and fuse with lysosomes for to the degradation pathway.
Please access this pathway at [http://www.netpath.org/netslim/EGFR1_pathway.html NetSlim] database.
If you use this pathway, please cite the following paper:
Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. <i>Genome Biology</i>. 11:R3.
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/20067622
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/20067622