SPARQL | HTML5 RDFa and Microdata document
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http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
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http://vocabularies.wikipathways.org/wp#ontologyTag
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
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http://vocabularies.wikipathways.org/wp#organismName
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http://purl.org/dc/elements/1.1/source
http://purl.org/dc/elements/1.1/title
http://purl.org/dc/terms/description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
http://purl.org/dc/terms/identifier
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https://identifiers.org/pubmed/11749383
https://identifiers.org/pubmed/12676795
https://identifiers.org/pubmed/12849693
https://identifiers.org/pubmed/12947395
https://identifiers.org/pubmed/14597384
https://identifiers.org/pubmed/12191611
https://identifiers.org/pubmed/12390245
https://identifiers.org/pubmed/12566928
https://identifiers.org/pubmed/11369511
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/11749383
https://identifiers.org/pubmed/11369511
https://identifiers.org/pubmed/17726008
https://identifiers.org/pubmed/22539006
https://identifiers.org/pubmed/12566928
https://identifiers.org/pubmed/12191611
https://identifiers.org/pubmed/12390245
https://identifiers.org/pubmed/14597384
https://identifiers.org/pubmed/12947395
https://identifiers.org/pubmed/12676795
https://identifiers.org/pubmed/12849693